Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity
Ethnopharmacological relevance: The Scutellaria barbata D.Don and Hedyotis diffusa Willd. (SH) herb pair is extensively used in Traditional Chinese medicine for treating cancer, which has a long history in clinical empirical prescriptions, such as ''kang ai ping wan (抗癌平丸)'', �...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | Pharmacological Research - Modern Chinese Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667142522000094 |
| _version_ | 1818320159579832320 |
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| author | Jiaxin Zhu Zhongtao Zhang Ruyi Wang Xiaoxian Huang Ya Zhou Kexin Zhang Keke Zhong Liangping Gong Yuan Li Wenyuan Liu Feng Feng Wei Qu |
| author_facet | Jiaxin Zhu Zhongtao Zhang Ruyi Wang Xiaoxian Huang Ya Zhou Kexin Zhang Keke Zhong Liangping Gong Yuan Li Wenyuan Liu Feng Feng Wei Qu |
| author_sort | Jiaxin Zhu |
| collection | DOAJ |
| description | Ethnopharmacological relevance: The Scutellaria barbata D.Don and Hedyotis diffusa Willd. (SH) herb pair is extensively used in Traditional Chinese medicine for treating cancer, which has a long history in clinical empirical prescriptions, such as ''kang ai ping wan (抗癌平丸)'', ''er ban er bai decoction (二半二白汤)''. The ambiguous pharmacological ingredients and compatibility mechanism of SH herb pair promoted the exploration. Aim of the study: The characteristics of phytochemicals self-recognition and self-assembly is used to quickly find the active nanoparticles in SH herb pair. And it provides a new strategy for the developing new drugs of TCM. Methods: The SH-extracted nanoparticles (NPs) were gained by centrifugating from the 70% fractionated that the biological activity-guided by D101 macroporous resin column. The micromorphology of active NPs was observed with transmission electron microscopy (TEM). Dynamic light scattering (DLS), Ultraviolet−visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and element analysis (EA) were applied for characterizing NPs. The main components were identified by high performance liquid chromatography (HPLC) and HPLC-Q-TOF-MS/MS. Proliferation and migration experiments in vitro as well as tumor growth in vivo were performed to evaluate NPs on triple negative breast cancer (TNBC). Results: The present article quickly discovered the key active ingredients from SH herb pair70%SH-NPs, which were mainly composed of aurantiamide acetate (from HD), scutebarbatine A (from SB) and palmitin (from HD). 70%SH-NPs significantly inhibited proliferation and migration of breast cancer cells in vitro together with tumor growth in nude mice. Conclusions: The results maybe explain the wisdom of SH herb pair compatibility, that is, the active ingredients of the two single drugs self-assemble to form NPs via supramolecular chemical bonds during the decoction process. In summary, the present article might inspire the studies of the relationship between active phytochemicals and NPs in herbs, and the corresponding pharmacological implications. |
| first_indexed | 2024-12-13T10:20:35Z |
| format | Article |
| id | doaj.art-f1cff39eaf7c4d6aa2509703fad5adbf |
| institution | Directory Open Access Journal |
| issn | 2667-1425 |
| language | English |
| last_indexed | 2024-12-13T10:20:35Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research - Modern Chinese Medicine |
| spelling | doaj.art-f1cff39eaf7c4d6aa2509703fad5adbf2022-12-21T23:51:12ZengElsevierPharmacological Research - Modern Chinese Medicine2667-14252022-03-012100048Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activityJiaxin Zhu0Zhongtao Zhang1Ruyi Wang2Xiaoxian Huang3Ya Zhou4Kexin Zhang5Keke Zhong6Liangping Gong7Yuan Li8Wenyuan Liu9Feng Feng10Wei Qu11Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of ChinaSchool of Pharmaceutical Engineering, Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu 223003, People's Republic of ChinaDepartment of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, People's Republic of ChinaDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of China; Jiangsu Food and Pharmaceutical Science College, Huaian, Jiangsu 223003, People's Republic of China; Corresponding author at: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of China.Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, People's Republic of China; Corresponding author.Ethnopharmacological relevance: The Scutellaria barbata D.Don and Hedyotis diffusa Willd. (SH) herb pair is extensively used in Traditional Chinese medicine for treating cancer, which has a long history in clinical empirical prescriptions, such as ''kang ai ping wan (抗癌平丸)'', ''er ban er bai decoction (二半二白汤)''. The ambiguous pharmacological ingredients and compatibility mechanism of SH herb pair promoted the exploration. Aim of the study: The characteristics of phytochemicals self-recognition and self-assembly is used to quickly find the active nanoparticles in SH herb pair. And it provides a new strategy for the developing new drugs of TCM. Methods: The SH-extracted nanoparticles (NPs) were gained by centrifugating from the 70% fractionated that the biological activity-guided by D101 macroporous resin column. The micromorphology of active NPs was observed with transmission electron microscopy (TEM). Dynamic light scattering (DLS), Ultraviolet−visible (UV-vis) spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and element analysis (EA) were applied for characterizing NPs. The main components were identified by high performance liquid chromatography (HPLC) and HPLC-Q-TOF-MS/MS. Proliferation and migration experiments in vitro as well as tumor growth in vivo were performed to evaluate NPs on triple negative breast cancer (TNBC). Results: The present article quickly discovered the key active ingredients from SH herb pair70%SH-NPs, which were mainly composed of aurantiamide acetate (from HD), scutebarbatine A (from SB) and palmitin (from HD). 70%SH-NPs significantly inhibited proliferation and migration of breast cancer cells in vitro together with tumor growth in nude mice. Conclusions: The results maybe explain the wisdom of SH herb pair compatibility, that is, the active ingredients of the two single drugs self-assemble to form NPs via supramolecular chemical bonds during the decoction process. In summary, the present article might inspire the studies of the relationship between active phytochemicals and NPs in herbs, and the corresponding pharmacological implications.http://www.sciencedirect.com/science/article/pii/S2667142522000094Scutellaria barbataHedyotis diffusaHerb pairNanoparticlesAnti-cancer |
| spellingShingle | Jiaxin Zhu Zhongtao Zhang Ruyi Wang Xiaoxian Huang Ya Zhou Kexin Zhang Keke Zhong Liangping Gong Yuan Li Wenyuan Liu Feng Feng Wei Qu Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity Pharmacological Research - Modern Chinese Medicine Scutellaria barbata Hedyotis diffusa Herb pair Nanoparticles Anti-cancer |
| title | Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity |
| title_full | Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity |
| title_fullStr | Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity |
| title_full_unstemmed | Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity |
| title_short | Nanoparticles derived from Scutellaria barbata and Hedytois diffusa herb pair and their anti-cancer activity |
| title_sort | nanoparticles derived from scutellaria barbata and hedytois diffusa herb pair and their anti cancer activity |
| topic | Scutellaria barbata Hedyotis diffusa Herb pair Nanoparticles Anti-cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2667142522000094 |
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