A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion
The 2013–2016 outbreak of Ebola virus disease in West Africa demonstrated the potential for previously localized outbreaks to turn into regional, or even global, health emergencies. With over 28,000 cases and 11,000 confirmed deaths, this outbreak was over 50 times as large as any previously recorde...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2021-02-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.03616-20 |
| _version_ | 1818904855776854016 |
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| author | J. Maximilian Fels Robert H. Bortz Tanwee Alkutkar Eva Mittler Rohit K. Jangra Jennifer S. Spence Kartik Chandran |
| author_facet | J. Maximilian Fels Robert H. Bortz Tanwee Alkutkar Eva Mittler Rohit K. Jangra Jennifer S. Spence Kartik Chandran |
| author_sort | J. Maximilian Fels |
| collection | DOAJ |
| description | The 2013–2016 outbreak of Ebola virus disease in West Africa demonstrated the potential for previously localized outbreaks to turn into regional, or even global, health emergencies. With over 28,000 cases and 11,000 confirmed deaths, this outbreak was over 50 times as large as any previously recorded. |
| first_indexed | 2024-12-19T21:14:04Z |
| format | Article |
| id | doaj.art-f1d1e84b329f4c3899c090a268e3d590 |
| institution | Directory Open Access Journal |
| issn | 2161-2129 2150-7511 |
| language | English |
| last_indexed | 2024-12-19T21:14:04Z |
| publishDate | 2021-02-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-f1d1e84b329f4c3899c090a268e3d5902022-12-21T20:05:25ZengAmerican Society for MicrobiologymBio2161-21292150-75112021-02-0112110.1128/mBio.03616-20A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane FusionJ. Maximilian Fels0https://orcid.org/0000-0003-1455-9318Robert H. Bortz1Tanwee Alkutkar2Eva Mittler3https://orcid.org/0000-0002-5935-6314Rohit K. Jangra4https://orcid.org/0000-0002-3119-0869Jennifer S. Spence5Kartik Chandran6https://orcid.org/0000-0003-0232-7077Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USADepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USAThe 2013–2016 outbreak of Ebola virus disease in West Africa demonstrated the potential for previously localized outbreaks to turn into regional, or even global, health emergencies. With over 28,000 cases and 11,000 confirmed deaths, this outbreak was over 50 times as large as any previously recorded.https://journals.asm.org/doi/10.1128/mBio.03616-20 |
| spellingShingle | J. Maximilian Fels Robert H. Bortz Tanwee Alkutkar Eva Mittler Rohit K. Jangra Jennifer S. Spence Kartik Chandran A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion mBio |
| title | A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion |
| title_full | A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion |
| title_fullStr | A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion |
| title_full_unstemmed | A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion |
| title_short | A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion |
| title_sort | glycoprotein mutation that emerged during the 2013 2016 ebola virus epidemic alters proteolysis and accelerates membrane fusion |
| url | https://journals.asm.org/doi/10.1128/mBio.03616-20 |
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