Defective Interfering RNAs: Foes of Viruses and Friends of Virologists
Defective interfering (DI) RNAs are subviral RNAs produced during multiplication of RNA viruses by the error-prone viral replicase. DI-RNAs are parasitic RNAs that are derived from and associated with the parent virus, taking advantage of viral-coded protein factors for their multiplication. Recent...
| Autori principali: | , |
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| Natura: | Articolo |
| Lingua: | English |
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MDPI AG
2009-11-01
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| Serie: | Viruses |
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| Accesso online: | http://www.mdpi.com/1999-4915/1/3/895/ |
| _version_ | 1830211059348144128 |
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| author | Peter D. Nagy Kunj B. Pathak |
| author_facet | Peter D. Nagy Kunj B. Pathak |
| author_sort | Peter D. Nagy |
| collection | DOAJ |
| description | Defective interfering (DI) RNAs are subviral RNAs produced during multiplication of RNA viruses by the error-prone viral replicase. DI-RNAs are parasitic RNAs that are derived from and associated with the parent virus, taking advantage of viral-coded protein factors for their multiplication. Recent advances in the field of DI RNA biology has led to a greater understanding about generation and evolution of DI-RNAs as well as the mechanism of symptom attenuation. Moreover, DI-RNAs are versatile tools in the hands of virologists and are used as less complex surrogate templates to understand the biology of their helper viruses. The ease of their genetic manipulation has resulted in rapid discoveries on cis-acting RNA replication elements required for replication and recombination. DI-RNAs have been further exploited to discover host factors that modulate Tomato bushy stunt virus replication, as well as viral RNA recombination. This review discusses the current models on generation and evolution of DI-RNAs, the roles of viral and host factors in DI-RNA replication, and the mechanisms of disease attenuation. |
| first_indexed | 2024-12-18T05:37:14Z |
| format | Article |
| id | doaj.art-f1d24e358a8b408bb4bcc6da247a7b60 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-12-18T05:37:14Z |
| publishDate | 2009-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-f1d24e358a8b408bb4bcc6da247a7b602022-12-21T21:19:16ZengMDPI AGViruses1999-49152009-11-011389591910.3390/v1030895Defective Interfering RNAs: Foes of Viruses and Friends of VirologistsPeter D. NagyKunj B. PathakDefective interfering (DI) RNAs are subviral RNAs produced during multiplication of RNA viruses by the error-prone viral replicase. DI-RNAs are parasitic RNAs that are derived from and associated with the parent virus, taking advantage of viral-coded protein factors for their multiplication. Recent advances in the field of DI RNA biology has led to a greater understanding about generation and evolution of DI-RNAs as well as the mechanism of symptom attenuation. Moreover, DI-RNAs are versatile tools in the hands of virologists and are used as less complex surrogate templates to understand the biology of their helper viruses. The ease of their genetic manipulation has resulted in rapid discoveries on cis-acting RNA replication elements required for replication and recombination. DI-RNAs have been further exploited to discover host factors that modulate Tomato bushy stunt virus replication, as well as viral RNA recombination. This review discusses the current models on generation and evolution of DI-RNAs, the roles of viral and host factors in DI-RNA replication, and the mechanisms of disease attenuation.http://www.mdpi.com/1999-4915/1/3/895/RNA virusRNA structurehost factorsreplicationrecombination |
| spellingShingle | Peter D. Nagy Kunj B. Pathak Defective Interfering RNAs: Foes of Viruses and Friends of Virologists Viruses RNA virus RNA structure host factors replication recombination |
| title | Defective Interfering RNAs: Foes of Viruses and Friends of Virologists |
| title_full | Defective Interfering RNAs: Foes of Viruses and Friends of Virologists |
| title_fullStr | Defective Interfering RNAs: Foes of Viruses and Friends of Virologists |
| title_full_unstemmed | Defective Interfering RNAs: Foes of Viruses and Friends of Virologists |
| title_short | Defective Interfering RNAs: Foes of Viruses and Friends of Virologists |
| title_sort | defective interfering rnas foes of viruses and friends of virologists |
| topic | RNA virus RNA structure host factors replication recombination |
| url | http://www.mdpi.com/1999-4915/1/3/895/ |
| work_keys_str_mv | AT peterdnagy defectiveinterferingrnasfoesofvirusesandfriendsofvirologists AT kunjbpathak defectiveinterferingrnasfoesofvirusesandfriendsofvirologists |