Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds
Organocatalytic asymmetric α-oxidation and amination reactions of carbonyl compounds are highly useful synthetic methodologies, especially in generating chiral building blocks that previously have not been easily accessible by traditional methods. The concept is relatively new and therefore the list...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-02-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/15/2/917/ |
| _version_ | 1811262940879257600 |
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| author | Worawan Bhanthumnavin Tirayut Vilaivan |
| author_facet | Worawan Bhanthumnavin Tirayut Vilaivan |
| author_sort | Worawan Bhanthumnavin |
| collection | DOAJ |
| description | Organocatalytic asymmetric α-oxidation and amination reactions of carbonyl compounds are highly useful synthetic methodologies, especially in generating chiral building blocks that previously have not been easily accessible by traditional methods. The concept is relatively new and therefore the list of new catalysts, oxidizing and aminating reagents, as well as new substrates, are expanding at an amazing rate. The scope of this review includes new reactions and catalysts, mechanistic aspects and synthetic applications of α-oxidation, hydroxylation, aminoxylation, amination, hydrazination, hydroxyamination and related α-heteroatom functionalization of aldehydes, ketones and related active methylene compounds published during 2005–2009. |
| first_indexed | 2024-04-12T19:35:53Z |
| format | Article |
| id | doaj.art-f1d39d4241b54b06b7d36777cc851c58 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-12T19:35:53Z |
| publishDate | 2010-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f1d39d4241b54b06b7d36777cc851c582022-12-22T03:19:14ZengMDPI AGMolecules1420-30492010-02-0115291795810.3390/molecules15020917Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl CompoundsWorawan BhanthumnavinTirayut VilaivanOrganocatalytic asymmetric α-oxidation and amination reactions of carbonyl compounds are highly useful synthetic methodologies, especially in generating chiral building blocks that previously have not been easily accessible by traditional methods. The concept is relatively new and therefore the list of new catalysts, oxidizing and aminating reagents, as well as new substrates, are expanding at an amazing rate. The scope of this review includes new reactions and catalysts, mechanistic aspects and synthetic applications of α-oxidation, hydroxylation, aminoxylation, amination, hydrazination, hydroxyamination and related α-heteroatom functionalization of aldehydes, ketones and related active methylene compounds published during 2005–2009.http://www.mdpi.com/1420-3049/15/2/917/organocatalystchiral catalystα-oxidationα-aminationα-aminoxylationnitrosoaldol reactionaldehydeketoneactive methylene compound |
| spellingShingle | Worawan Bhanthumnavin Tirayut Vilaivan Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds Molecules organocatalyst chiral catalyst α-oxidation α-amination α-aminoxylation nitrosoaldol reaction aldehyde ketone active methylene compound |
| title | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds |
| title_full | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds |
| title_fullStr | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds |
| title_full_unstemmed | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds |
| title_short | Organocatalyzed Asymmetric α-Oxidation, α-Aminoxylation and α-Amination of Carbonyl Compounds |
| title_sort | organocatalyzed asymmetric α oxidation α aminoxylation and α amination of carbonyl compounds |
| topic | organocatalyst chiral catalyst α-oxidation α-amination α-aminoxylation nitrosoaldol reaction aldehyde ketone active methylene compound |
| url | http://www.mdpi.com/1420-3049/15/2/917/ |
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