Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context
Summary: Background: We describe the epidemiology, clinical features and outcome of adult meningococcal meningitis in the Netherlands over a 15-year period. Methods: We studied adults (age ≥ 16 years) who were listed by the Netherlands Reference Laboratory for Bacterial Meningitis and/or included i...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-07-01
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| Series: | The Lancet Regional Health. Europe |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666776223000595 |
| _version_ | 1797836921918980096 |
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| author | Thijs M. van Soest Nora Chekrouni Nina M. van Sorge Merijn W. Bijlsma Matthijs C. Brouwer Diederik van de Beek |
| author_facet | Thijs M. van Soest Nora Chekrouni Nina M. van Sorge Merijn W. Bijlsma Matthijs C. Brouwer Diederik van de Beek |
| author_sort | Thijs M. van Soest |
| collection | DOAJ |
| description | Summary: Background: We describe the epidemiology, clinical features and outcome of adult meningococcal meningitis in the Netherlands over a 15-year period. Methods: We studied adults (age ≥ 16 years) who were listed by the Netherlands Reference Laboratory for Bacterial Meningitis and/or included in the prospective nationwide cohort study (MeninGene) between January 2006 and July 2021. Incidences were calculated per epidemiological year (July–June). Findings: We identified 442 episodes of adult meningococcal meningitis. The median patient age was 32 years (IQR 18–55) and 226 episodes (51%) occurred in female patients. The annual incidence per 100,000 adults fluctuated, from 0.33 in 2006–2007 to 0.05 in 2020–2021, with a temporal increase up to 0.30 from 2016 to 2018, driven by an outbreak of serogroup W (MenW). Of 442 episodes, 274 episodes (62%) in 273 patients were included in the clinical cohort study. The overall case fatality rate was 4% (10 of 274) and 16% (43 of 274) had an unfavourable outcome (Glasgow Outcome Scale score 1–4). Compared to other serogroups, MenW was associated with higher rates of unfavourable outcome (6 of 16 [38%] vs. 37 of 251 [15%], P = 0.03) and death (4 of 16 [25%] vs. 6 of 251 [2%], P = 0.001). Interpretation: The overall incidence of adult meningococcal meningitis in the Netherlands is low and outcome is generally favourable. An increase of MenW meningitis occurred from 2016 to 2018, which was associated with more unfavourable outcome and death. Funding: Netherlands Organisation for Health Research and Development, European Research Council, National Institute of Public Health and Environmental protection. |
| first_indexed | 2024-04-09T15:16:40Z |
| format | Article |
| id | doaj.art-f1d3fa9d92244f6c85f8aeb3b6159796 |
| institution | Directory Open Access Journal |
| issn | 2666-7762 |
| language | English |
| last_indexed | 2024-04-09T15:16:40Z |
| publishDate | 2023-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Lancet Regional Health. Europe |
| spelling | doaj.art-f1d3fa9d92244f6c85f8aeb3b61597962023-04-29T14:59:11ZengElsevierThe Lancet Regional Health. Europe2666-77622023-07-0130100640Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in contextThijs M. van Soest0Nora Chekrouni1Nina M. van Sorge2Merijn W. Bijlsma3Matthijs C. Brouwer4Diederik van de Beek5Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Location University of Amsterdam, Meibergdreef, Amsterdam, the NetherlandsDepartment of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Location University of Amsterdam, Meibergdreef, Amsterdam, the NetherlandsDepartment of Medical Microbiology and Infection Prevention, Amsterdam UMC Location University of Amsterdam, Amsterdam Institute for Infection and Immunity, Meibergdreef, Amsterdam, the Netherlands; Netherlands Reference Laboratory for Bacterial Meningitis, Amsterdam UMC Location AMC, Amsterdam, the NetherlandsDepartment of Paediatrics, Amsterdam Neuroscience, Amsterdam UMC Location University of Amsterdam, Meibergdreef, Amsterdam, the NetherlandsDepartment of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Location University of Amsterdam, Meibergdreef, Amsterdam, the NetherlandsDepartment of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Location University of Amsterdam, Meibergdreef, Amsterdam, the Netherlands; Corresponding author. Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, PO Box 22660, 1100DD, Amsterdam, the Netherlands.Summary: Background: We describe the epidemiology, clinical features and outcome of adult meningococcal meningitis in the Netherlands over a 15-year period. Methods: We studied adults (age ≥ 16 years) who were listed by the Netherlands Reference Laboratory for Bacterial Meningitis and/or included in the prospective nationwide cohort study (MeninGene) between January 2006 and July 2021. Incidences were calculated per epidemiological year (July–June). Findings: We identified 442 episodes of adult meningococcal meningitis. The median patient age was 32 years (IQR 18–55) and 226 episodes (51%) occurred in female patients. The annual incidence per 100,000 adults fluctuated, from 0.33 in 2006–2007 to 0.05 in 2020–2021, with a temporal increase up to 0.30 from 2016 to 2018, driven by an outbreak of serogroup W (MenW). Of 442 episodes, 274 episodes (62%) in 273 patients were included in the clinical cohort study. The overall case fatality rate was 4% (10 of 274) and 16% (43 of 274) had an unfavourable outcome (Glasgow Outcome Scale score 1–4). Compared to other serogroups, MenW was associated with higher rates of unfavourable outcome (6 of 16 [38%] vs. 37 of 251 [15%], P = 0.03) and death (4 of 16 [25%] vs. 6 of 251 [2%], P = 0.001). Interpretation: The overall incidence of adult meningococcal meningitis in the Netherlands is low and outcome is generally favourable. An increase of MenW meningitis occurred from 2016 to 2018, which was associated with more unfavourable outcome and death. Funding: Netherlands Organisation for Health Research and Development, European Research Council, National Institute of Public Health and Environmental protection.http://www.sciencedirect.com/science/article/pii/S2666776223000595Meningococcal meningitisEpidemiologyClinical featuresOutcome |
| spellingShingle | Thijs M. van Soest Nora Chekrouni Nina M. van Sorge Merijn W. Bijlsma Matthijs C. Brouwer Diederik van de Beek Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context The Lancet Regional Health. Europe Meningococcal meningitis Epidemiology Clinical features Outcome |
| title | Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context |
| title_full | Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context |
| title_fullStr | Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context |
| title_full_unstemmed | Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context |
| title_short | Epidemiology, clinical features and outcome of adults with meningococcal meningitis: a 15-year prospective nationwide cohort studyResearch in context |
| title_sort | epidemiology clinical features and outcome of adults with meningococcal meningitis a 15 year prospective nationwide cohort studyresearch in context |
| topic | Meningococcal meningitis Epidemiology Clinical features Outcome |
| url | http://www.sciencedirect.com/science/article/pii/S2666776223000595 |
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