A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction
Transsynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-09-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1601433703988-237020442.pdf |
| _version_ | 1818056272527753216 |
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| author | Yi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang |
| author_facet | Yi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang |
| author_sort | Yi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang |
| collection | DOAJ |
| description | Transsynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and ocular symptoms. Any lesions interrupting the dentate-rubro-olivary pathway, referred to as the anatomic Guillain-Mollaret triangle, contribute to the broad aetiologies of hypertrophic olivary degeneration. The clinical diagnosis depends primarily on the associated symptoms and the characteristic magnetic resonance imaging findings. Concerning treatment and prognosis, there are no widely accepted guidelines. Here, we identified 11 cases of hypertrophic olivary degeneration secondary to brainstem infarction from 1964 to the present. Combined with two of our cases, the clinical and imaging findings of 13 patients with hypertrophic olivary degeneration secondary to brainstem infarction were studied. A meta-analysis of case studies gives the correlation coefficient between infraction location and time to develop hypertrophic olivary degeneration as 0.217 (P = 0.393, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and time to develop hypertrophic olivary degeneration. The χ2 between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration was 8.750 (P = 0.364, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration. Conclusion based on the analysis of available data suggests that when newly developed or progressive worsening motor symptoms are presented in patients with previous brainstem infarction, a diagnosis of hypertrophic olivary degeneration should be investigated. |
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| format | Article |
| id | doaj.art-f1d4b66ab0f043af95c1ad968e7ca800 |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-12-10T12:26:12Z |
| publishDate | 2020-09-01 |
| publisher | IMR Press |
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| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-f1d4b66ab0f043af95c1ad968e7ca8002022-12-22T01:48:57ZengIMR PressJournal of Integrative Neuroscience1757-448X2020-09-0119350751110.31083/j.jin.2020.03.1238A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarctionYi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang01Department of Neurology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning, 110004, P. R. ChinaTranssynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and ocular symptoms. Any lesions interrupting the dentate-rubro-olivary pathway, referred to as the anatomic Guillain-Mollaret triangle, contribute to the broad aetiologies of hypertrophic olivary degeneration. The clinical diagnosis depends primarily on the associated symptoms and the characteristic magnetic resonance imaging findings. Concerning treatment and prognosis, there are no widely accepted guidelines. Here, we identified 11 cases of hypertrophic olivary degeneration secondary to brainstem infarction from 1964 to the present. Combined with two of our cases, the clinical and imaging findings of 13 patients with hypertrophic olivary degeneration secondary to brainstem infarction were studied. A meta-analysis of case studies gives the correlation coefficient between infraction location and time to develop hypertrophic olivary degeneration as 0.217 (P = 0.393, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and time to develop hypertrophic olivary degeneration. The χ2 between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration was 8.750 (P = 0.364, P > 0.05). At the significance level of P < 0.05, there was no significant correlation between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration. Conclusion based on the analysis of available data suggests that when newly developed or progressive worsening motor symptoms are presented in patients with previous brainstem infarction, a diagnosis of hypertrophic olivary degeneration should be investigated.https://jin.imrpress.com/fileup/1757-448X/PDF/1601433703988-237020442.pdf|hypertrophic olivary degeneration|brainstem|guillain-mollaret triangle|inferior olive nucleus|magnetic resonance imaging|neurological dysfunction |
| spellingShingle | Yi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction Journal of Integrative Neuroscience |hypertrophic olivary degeneration|brainstem|guillain-mollaret triangle|inferior olive nucleus|magnetic resonance imaging|neurological dysfunction |
| title | A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| title_full | A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| title_fullStr | A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| title_full_unstemmed | A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| title_short | A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| title_sort | meta analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction |
| topic | |hypertrophic olivary degeneration|brainstem|guillain-mollaret triangle|inferior olive nucleus|magnetic resonance imaging|neurological dysfunction |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1601433703988-237020442.pdf |
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