Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis

Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis

Abstract Background Bone regeneration is a complex procedure that involves an interaction between osteogenesis and inflammation. Macrophages in the microenvironment are instrumental in bone metabolism. Amount evidence have revealed that exosomes transmitting lncRNA is crucial nanocarriers for cellul...

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Bibliographic Details
Main Authors: Yuxuan Chen, Yuanhao Wu, Linlin Guo, Shijie Yuan, Jiaming Sun, Kangcheng Zhao, Jiecong Wang, Ran An
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Nanobiotechnology
Subjects:
Exosome
Macrophage polarization
NEAT1
Osteogenesis
Inflammation
Online Access:https://doi.org/10.1186/s12951-023-01855-w

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