Adoptive neoantigen-reactive T cell therapy: improvement strategies and current clinical researches

Adoptive neoantigen-reactive T cell therapy: improvement strategies and current clinical researches

Abstract Neoantigens generated by non-synonymous mutations of tumor genes can induce activation of neoantigen-reactive T (NRT) cells which have the ability to resist the growth of tumors expressing specific neoantigens. Immunotherapy based on NRT cells has made preeminent achievements in melanoma an...

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Bibliographic Details
Main Authors: Ruichen Huang, Bi Zhao, Shi Hu, Qian Zhang, Xiaoping Su, Wei Zhang
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Biomarker Research
Subjects:
Neoantigen-reactive T cell
Adoptive cell therapy
Immunotherapy
Cancer
Online Access:https://doi.org/10.1186/s40364-023-00478-5

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