Synthesis, Molecular Docking, and Biological Evaluation of Novel Anthranilic Acid Hybrid and Its Diamides as Antispasmodics

Synthesis, Molecular Docking, and Biological Evaluation of Novel Anthranilic Acid Hybrid and Its Diamides as Antispasmodics

The present article focuses on the synthesis and biological evaluation of a novel anthranilic acid hybrid and its diamides as antispasmodics. Methods: Due to the predicted in silico methods spasmolytic activity, we synthesized a hybrid molecule of anthranilic acid and 2-(3-chlorophenyl)ethylamine. T...

Full description

Bibliographic Details
Main Authors:	Miglena Milusheva, Vera Gledacheva, Iliyana Stefanova, Mehran Feizi-Dehnayebi, Rositsa Mihaylova, Paraskev Nedialkov, Emiliya Cherneva, Yulian Tumbarski, Slava Tsoneva, Mina Todorova, Stoyanka Nikolova
Format:	Article
Language:	English
Published:	MDPI AG 2023-09-01
Series:	International Journal of Molecular Sciences
Subjects:	anthranilic acid hybrid molecules in silico DFT antiproliferative antimicrobial
Online Access:	https://www.mdpi.com/1422-0067/24/18/13855

Similar Items

Novel Anthranilic Acid Hybrids—An Alternative Weapon against Inflammatory Diseases
by: Miglena Milusheva, et al.
Published: (2023-11-01)

In Silico, In Vitro, and Ex Vivo Biological Activity of Some Novel Mebeverine Precursors
by: Miglena Milusheva, et al.
Published: (2023-02-01)

Anthranilic diamide compounds: Discovery of tetrachlorantraniliprole
by: Huibin Yang, et al.
Published: (2023-12-01)

Drug-Delivery Silver Nanoparticles: A New Perspective for Phenindione as an Anticoagulant
by: Stoyanka Nikolova, et al.
Published: (2023-08-01)

Engineering of Saccharomyces cerevisiae for anthranilate and methyl anthranilate production
by: Joosu Kuivanen, et al.
Published: (2021-02-01)

Synthesis, Physicochemical Properties, and Biological Activities of 4-(<i>S</i>-Methyl-<i>N</i>-(2,2,2-Trifluoroacetyl)Sulfilimidoyl) Anthranilic Diamide
by: Hwan Jung Lim, et al.
Published: (2019-09-01)

First report of field resistance to cyantraniliprole, a new anthranilic diamide insecticide, on Bemisia tabaci MED in China
by: Ran WANG, et al.
Published: (2018-01-01)

Influence of Rice Seeding Rate on Efficacies of Neonicotinoid and Anthranilic Diamide Seed Treatments against Rice Water Weevil
by: Jason Hamm, et al.
Published: (2014-12-01)

Anthranilate Acts as a Signal to Modulate Biofilm Formation, Virulence, and Antibiotic Tolerance of Pseudomonas aeruginosa and Surrounding Bacteria
by: Hyeon-Ji Hwang, et al.
Published: (2022-02-01)

1-(2-Chlorophenyl)-6,7-dimethoxy-3-methyl-3,4-dihydroisoquinoline
by: Miglena Milusheva, et al.
Published: (2023-03-01)

Microbial-Derived Tryptophan Metabolites and Their Role in Neurological Disease: Anthranilic Acid and Anthranilic Acid Derivatives
by: Claire Shaw, et al.
Published: (2023-07-01)

Anticancer, Antimicrobial, and Antioxidant Activities of Organodiselenide-Tethered Methyl Anthranilates
by: Batool Al-Abdallah, et al.
Published: (2022-11-01)

Intercalation of Anthranilate Ion Into Zinc-Aluminium-Layered Double Hydroxide
by: Mazidah Mamat, et al.
Published: (2014-01-01)

Structural Investigation for Optimization of Anthranilic Acid Derivatives as Partial FXR Agonists by in Silico Approaches
by: Meimei Chen, et al.
Published: (2016-04-01)

Involvement of Phenazines and Anthranilate in the Antagonism of Pseudomonas aeruginosa PNA1 and Tn5 Derivatives Toward Fusarium spp. and Pythium spp.
by: Vanamala Anjaiah, et al.
Published: (1998-09-01)

Organoselenocyanates Tethered Methyl Anthranilate Hybrids with Promising Anticancer, Antimicrobial, and Antioxidant Activities
by: Batool Al-Abdallah, et al.
Published: (2022-12-01)

Some Metal Ions Complexes Derived From Schiff Base Ligand with Anthranillic Acid: Preparation, Spectroscopic and Biological Studies
by: lekaa khalid karem
Published: (2020-03-01)

Synthesis of metal anthranilate complexes: catalytic and antipathogenic studies
by: Muhammad Nawaz, et al.
Published: (2022-03-01)

Transition Metal-Free Synthesis of 3-Acylquinolines through Formal [4+2] Annulation of Anthranils and Enaminones
by: Kai-Ling Zhang, et al.
Published: (2023-04-01)

Modulating the electronic structure of amino acids: interaction of model lewis acids with anthranilic acid
by: Tareq Irshaidat
Published: (2014-01-01)

Identification of a methyltransferase catalyzing the final step of methyl anthranilate synthesis in cultivated strawberry
by: Jeremy Pillet, et al.
Published: (2017-08-01)

An Anthranilate Derivative Inhibits Glutamate Release and Glutamate Excitotoxicity in Rats
by: Cheng-Wei Lu, et al.
Published: (2022-02-01)

Engineered Escherichia coli cell factory for anthranilate over-production
by: Hye-Jin Kim, et al.
Published: (2023-03-01)

Spectrophotometric Determination of Paracetamol by Diazotization and Coupling Reaction with Anthranilic Acid
by: Mohammed S. Abdul- Raheem, et al.
Published: (2017-03-01)

3-hydroxi-anthranilic acid is early expressed in stroke
by: A. Mangas, et al.
Published: (2016-12-01)

Development and Characterization of Methyl-Anthranilate-Loaded Silver Nanoparticles: A Phytocosmetic Sunscreen Gel for UV Protection
by: Mohammed Ghazwani, et al.
Published: (2023-05-01)

Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44
by: Bin-Gui Wang, et al.
Published: (2013-08-01)

Antimicrobial activity and mode of action of terpene linalyl anthranilate against carbapenemase-producing Klebsiella pneumoniae
by: Shun-Kai Yang, et al.
Published: (2021-04-01)

Down regulation of cotton GbTRP1 leads to accumulation of anthranilates and confers resistance to Verticillium dahliae
by: Yuhuan MIAO, et al.
Published: (2019-11-01)

Furanones and Anthranilic Acid Derivatives from the Endophytic Fungus Dendrothyrium variisporum
by: Rémy B. Teponno, et al.
Published: (2017-10-01)

Synthesis of New Azo Compounds and Their Application for a Simple Spectrophotometric Determination of Methyldopa Drug Using Anthranilic Acid and 2-Aminopyrimidine as Reagents
by: Ekhlas ABD ALKAREEM, et al.
Published: (2023-08-01)

Flavouring Group Evaluation 84, (FGE.84) ‐ Consideration of Anthranilate derivatives evaluated by JECFA (65th meeting) ‐ Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food
by: European Food Safety Authority (EFSA)
Published: (2008-11-01)

Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification
by: Léo Faïon, et al.
Published: (2023-02-01)

QSAR Study of Anthranilic Acid Sulfonamides as Inhibitors of Methionine Aminopeptidase-2 using different chemometrics tools
by: Pooria Zare, et al.
Published: (2023-03-01)

Metabolic engineering of Pseudomonas putida KT2440 to produce anthranilate from glucose
by: Jannis eKuepper, et al.
Published: (2015-11-01)

Pilot-Scale Processing and Functional Properties of Antifungal EVOH-Based Films Containing Methyl Anthranilate Intended for Food Packaging Applications
by: Alejandro Aragón-Gutiérrez, et al.
Published: (2022-08-01)

Synthesis and Biological Evaluation of New Quinoline and Anthranilic Acid Derivatives as Potential Quorum Sensing Inhibitors
by: Ivana Perković, et al.
Published: (2023-08-01)

Fluorescent Probes for Insect Ryanodine Receptors: Candidate Anthranilic Diamides
by: Yi Wang, et al.
Published: (2014-04-01)

Exploring the Dual Inhibitory Activity of Novel Anthranilic Acid Derivatives towards α-Glucosidase and Glycogen Phosphorylase Antidiabetic Targets: Design, In Vitro Enzyme Assay, and Docking Studies
by: Saleh Ihmaid
Published: (2018-05-01)

Kynurenine pathway activation and deviation to anthranilic and kynurenic acid in fibrosing chronic graft-versus-host disease
by: Laura Orsatti, et al.
Published: (2021-10-01)