Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome
Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared...
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MDPI AG
2022-01-01
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| Online Access: | https://www.mdpi.com/2076-3425/12/2/204 |
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| author | Sebastian Schuster Leonie Beyer Carla Palleis Stefanie Harris Julia Schmitt Endy Weidinger Catharina Prix Kai Bötzel Adrian Danek Boris-Stephan Rauchmann Sophia Stöcklein Simon Lindner Marcus Unterrainer Nathalie L. Albert Lena M. Mittlmeier Christian Wetzel Rainer Rupprecht Axel Rominger Peter Bartenstein Robert Perneczky Johannes Levin Günter U. Höglinger Matthias Brendel Franziska J. Dekorsy |
| author_facet | Sebastian Schuster Leonie Beyer Carla Palleis Stefanie Harris Julia Schmitt Endy Weidinger Catharina Prix Kai Bötzel Adrian Danek Boris-Stephan Rauchmann Sophia Stöcklein Simon Lindner Marcus Unterrainer Nathalie L. Albert Lena M. Mittlmeier Christian Wetzel Rainer Rupprecht Axel Rominger Peter Bartenstein Robert Perneczky Johannes Levin Günter U. Höglinger Matthias Brendel Franziska J. Dekorsy |
| author_sort | Sebastian Schuster |
| collection | DOAJ |
| description | Corticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [<sup>18</sup>F]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [<sup>18</sup>F]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (<i>p</i> = 0.041), the left putamen (<i>p</i> = 0.005), the right putamen (<i>p</i> = 0.038) and the left pallidum (<i>p</i> = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [<sup>18</sup>F]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly. |
| first_indexed | 2024-03-09T22:27:30Z |
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| institution | Directory Open Access Journal |
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| publishDate | 2022-01-01 |
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| spelling | doaj.art-f1d55e58be4b47388f8f9251c12ada542023-11-23T19:03:13ZengMDPI AGBrain Sciences2076-34252022-01-0112220410.3390/brainsci12020204Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal SyndromeSebastian Schuster0Leonie Beyer1Carla Palleis2Stefanie Harris3Julia Schmitt4Endy Weidinger5Catharina Prix6Kai Bötzel7Adrian Danek8Boris-Stephan Rauchmann9Sophia Stöcklein10Simon Lindner11Marcus Unterrainer12Nathalie L. Albert13Lena M. Mittlmeier14Christian Wetzel15Rainer Rupprecht16Axel Rominger17Peter Bartenstein18Robert Perneczky19Johannes Levin20Günter U. Höglinger21Matthias Brendel22Franziska J. Dekorsy23Department of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Radiology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, GermanyDepartment of Psychiatry and Psychotherapy, University of Regensburg, 93053 Regensburg, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyMunich Cluster for Systems Neurology (SyNergy), 81377 Munich, GermanyDepartment of Neurology, University Hospital of Munich, Ludwig Maximilian University of Munich, 81377 Munich, GermanyMunich Cluster for Systems Neurology (SyNergy), 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyDepartment of Nuclear Medicine, University Hospital, Ludwig Maximilian University of Munich, 81377 Munich, GermanyCorticobasal syndrome (CBS) is a rare neurodegenerative condition characterized by four-repeat tau aggregation in the cortical and subcortical brain regions and accompanied by severe atrophy. The aim of this study was to evaluate partial volume effect correction (PVEC) in patients with CBS compared to a control cohort imaged with the 18-kDa translocator protein (TSPO) positron emission tomography (PET) tracer [<sup>18</sup>F]GE-180. Eighteen patients with CBS and 12 age- and sex-matched healthy controls underwent [<sup>18</sup>F]GE-180 PET. The cortical and subcortical regions were delineated by deep nuclei parcellation (DNP) of a 3D-T1 MRI. Region-specific subcortical volumes and standardized uptake values and ratios (SUV and SUVr) were extracted before and after region-based voxel-wise PVEC. Regional volumes were compared between patients with CBS and controls. The % group differences and effect sizes (CBS vs. controls) of uncorrected and PVE-corrected SUVr data were compared. Single-region positivity in patients with CBS was assessed by a >2 SD threshold vs. controls and compared between uncorrected and PVE-corrected data. Smaller regional volumes were detected in patients with CBS compared to controls in the right ventral striatum (<i>p</i> = 0.041), the left putamen (<i>p</i> = 0.005), the right putamen (<i>p</i> = 0.038) and the left pallidum (<i>p</i> = 0.015). After applying PVEC, the % group differences were distinctly higher, but the effect sizes of TSPO uptake were only slightly stronger due to the higher variance after PVEC. The single-region positivity of TSPO PET increased in patients with CBS after PVEC (100 vs. 83 regions). PVEC in the cortical and subcortical regions is valuable for TSPO imaging of patients with CBS, leading to the improved detection of elevated [<sup>18</sup>F]GE-180 uptake, although the effect sizes in the comparison against the controls did not improve strongly.https://www.mdpi.com/2076-3425/12/2/204corticobasal syndromepartial volume effectpositron emission tomographyTSPO PET[<sup>18</sup>F]GE-180subcortical atrophy |
| spellingShingle | Sebastian Schuster Leonie Beyer Carla Palleis Stefanie Harris Julia Schmitt Endy Weidinger Catharina Prix Kai Bötzel Adrian Danek Boris-Stephan Rauchmann Sophia Stöcklein Simon Lindner Marcus Unterrainer Nathalie L. Albert Lena M. Mittlmeier Christian Wetzel Rainer Rupprecht Axel Rominger Peter Bartenstein Robert Perneczky Johannes Levin Günter U. Höglinger Matthias Brendel Franziska J. Dekorsy Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome Brain Sciences corticobasal syndrome partial volume effect positron emission tomography TSPO PET [<sup>18</sup>F]GE-180 subcortical atrophy |
| title | Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
| title_full | Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
| title_fullStr | Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
| title_full_unstemmed | Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
| title_short | Impact of Partial Volume Correction on [<sup>18</sup>F]GE-180 PET Quantification in Subcortical Brain Regions of Patients with Corticobasal Syndrome |
| title_sort | impact of partial volume correction on sup 18 sup f ge 180 pet quantification in subcortical brain regions of patients with corticobasal syndrome |
| topic | corticobasal syndrome partial volume effect positron emission tomography TSPO PET [<sup>18</sup>F]GE-180 subcortical atrophy |
| url | https://www.mdpi.com/2076-3425/12/2/204 |
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