The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes

The role of activation of two different sGC binding sites by NO‐dependent and NO‐independent mechanisms in the regulation of SACs in rat ventricular cardiomyocytes

Abstract The mechanoelectrical feedback (MEF) mechanism in the heart that plays a significant role in the occurrence of arrhythmias, involves cation flux through cation nonselective stretch‐activated channels (SACs). It is well known that nitric oxide (NO) can act as a regulator of MEF. Here we addr...

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Bibliographic Details
Main Authors: Andre G. Kamkin, Olga V. Kamkina, Andrey L. Shim, Andrey Bilichenko, Vadim M. Mitrokhin, Viktor E. Kazansky, Tatiana S. Filatova, Denis V. Abramochkin, Mitko I. Mladenov
Format: Article
Language:English
Published: Wiley 2022-04-01
Series:Physiological Reports
Subjects:
8Br‐cGMP
ascorbic acid
BAY41‐2272
KT5823
L‐Arginine
nitric oxide
Online Access:https://doi.org/10.14814/phy2.15246

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