The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy
Abstract Background Prehabilitation has been shown to have a positive effect on the postoperative recovery of functional capacity in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. The optimal way to implement prehabilitation programs, such as the optimal forms of prehabil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-03-01
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| Series: | Trials |
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| Online Access: | https://doi.org/10.1186/s13063-023-07220-4 |
| _version_ | 1797863640880119808 |
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| author | Yuchao Liu Zijia Liu Yuelun Zhang Yushang Cui Lijian Pei Yuguang Huang |
| author_facet | Yuchao Liu Zijia Liu Yuelun Zhang Yushang Cui Lijian Pei Yuguang Huang |
| author_sort | Yuchao Liu |
| collection | DOAJ |
| description | Abstract Background Prehabilitation has been shown to have a positive effect on the postoperative recovery of functional capacity in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. The optimal way to implement prehabilitation programs, such as the optimal forms of prehabilitation, duration, intensity, and methods to improve compliance, remained to be studied. This Prehabilitation for Thoracic Surgery Study will compare the effectiveness of multimodal and aerobic training-only programs in patients undergoing thoracoscopic lobectomy. Methods This randomized pragmatic trial will be conducted in Peking Union Medical College Hospital (PUMCH) and include 100 patients who are eligible to undergo VATS lobectomy. Patients will be randomized to a multimodal or aerobic training group. Prehabilitation training guidance will be provided by a multidisciplinary care team. The patients in the multimodal group will perform aerobic exercises, resistance exercises, breathing exercises, psychological improvement strategies, and nutritional supplementation. Meanwhile, the patients in the aerobic group will conduct only aerobic exercises. The interventions will be home-based and supervised by medical providers. The patients will be followed up until 30 days after surgery to investigate whether the multimodal prehabilitation program differs from the aerobic training program in terms of the magnitude of improvement in functional capability pre- to postoperatively. The primary outcome will be the perioperative 6-min walk distance (6MWD). The secondary outcomes will include the postoperative pulmonary functional recovery status, health-related quality of life score, incidence of postoperative complications, and clinical outcomes. Discussion Prehabilitation remains a relatively new approach that is not widely performed by thoracic surgery patients. The existing studies mainly focus on unimodal interventions. While multimodal prehabilitation strategies have been shown to be preferable to unimodal strategies in a few studies, the evidence remains scarce for thoracic surgery patients. The results of this study will contribute to the understanding of methods for thoracoscopic lobectomy patients. Trial registration ClinicalTrials.gov NCT04049942 . Registered on August 8, 2019. |
| first_indexed | 2024-04-09T22:39:57Z |
| format | Article |
| id | doaj.art-f1d5c7a7aefc440097d47b839a88dc3b |
| institution | Directory Open Access Journal |
| issn | 1745-6215 |
| language | English |
| last_indexed | 2024-04-09T22:39:57Z |
| publishDate | 2023-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Trials |
| spelling | doaj.art-f1d5c7a7aefc440097d47b839a88dc3b2023-03-22T12:18:20ZengBMCTrials1745-62152023-03-012411910.1186/s13063-023-07220-4The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomyYuchao Liu0Zijia Liu1Yuelun Zhang2Yushang Cui3Lijian Pei4Yuguang Huang5Department of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalDepartment of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalDepartment of Medical Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalDepartment of Thoracic Surgery, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalDepartment of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalDepartment of Anesthesiology, Chinese Academy of Medical Sciences & Peking Union Medical College HospitalAbstract Background Prehabilitation has been shown to have a positive effect on the postoperative recovery of functional capacity in patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy. The optimal way to implement prehabilitation programs, such as the optimal forms of prehabilitation, duration, intensity, and methods to improve compliance, remained to be studied. This Prehabilitation for Thoracic Surgery Study will compare the effectiveness of multimodal and aerobic training-only programs in patients undergoing thoracoscopic lobectomy. Methods This randomized pragmatic trial will be conducted in Peking Union Medical College Hospital (PUMCH) and include 100 patients who are eligible to undergo VATS lobectomy. Patients will be randomized to a multimodal or aerobic training group. Prehabilitation training guidance will be provided by a multidisciplinary care team. The patients in the multimodal group will perform aerobic exercises, resistance exercises, breathing exercises, psychological improvement strategies, and nutritional supplementation. Meanwhile, the patients in the aerobic group will conduct only aerobic exercises. The interventions will be home-based and supervised by medical providers. The patients will be followed up until 30 days after surgery to investigate whether the multimodal prehabilitation program differs from the aerobic training program in terms of the magnitude of improvement in functional capability pre- to postoperatively. The primary outcome will be the perioperative 6-min walk distance (6MWD). The secondary outcomes will include the postoperative pulmonary functional recovery status, health-related quality of life score, incidence of postoperative complications, and clinical outcomes. Discussion Prehabilitation remains a relatively new approach that is not widely performed by thoracic surgery patients. The existing studies mainly focus on unimodal interventions. While multimodal prehabilitation strategies have been shown to be preferable to unimodal strategies in a few studies, the evidence remains scarce for thoracic surgery patients. The results of this study will contribute to the understanding of methods for thoracoscopic lobectomy patients. Trial registration ClinicalTrials.gov NCT04049942 . Registered on August 8, 2019.https://doi.org/10.1186/s13063-023-07220-4Multimodal prehabilitationAerobic trainingVideo-assisted thoracoscopic surgeriesLobectomyPragmatic trialFunctional capacity |
| spellingShingle | Yuchao Liu Zijia Liu Yuelun Zhang Yushang Cui Lijian Pei Yuguang Huang The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy Trials Multimodal prehabilitation Aerobic training Video-assisted thoracoscopic surgeries Lobectomy Pragmatic trial Functional capacity |
| title | The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy |
| title_full | The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy |
| title_fullStr | The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy |
| title_full_unstemmed | The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy |
| title_short | The protocol for the prehabilitation for thoracic surgery study: a randomized pragmatic trial comparing a short home-based multimodal program to aerobic training in patients undergoing video-assisted thoracoscopic surgery lobectomy |
| title_sort | protocol for the prehabilitation for thoracic surgery study a randomized pragmatic trial comparing a short home based multimodal program to aerobic training in patients undergoing video assisted thoracoscopic surgery lobectomy |
| topic | Multimodal prehabilitation Aerobic training Video-assisted thoracoscopic surgeries Lobectomy Pragmatic trial Functional capacity |
| url | https://doi.org/10.1186/s13063-023-07220-4 |
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