Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents
Three new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2005-07-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/HtDocs/SHD/vol70/No7/JSCS_V70_No7-07.pdf |
| _version_ | 1818963680764624896 |
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| author | KANAKAPURA BASAVAIAH UMAKANTHAPPA CHANDRASHEKAR PAREGOWDA NAGE GOWDA |
| author_facet | KANAKAPURA BASAVAIAH UMAKANTHAPPA CHANDRASHEKAR PAREGOWDA NAGE GOWDA |
| author_sort | KANAKAPURA BASAVAIAH |
| collection | DOAJ |
| description | Three new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was treated with a measured excess of the bromate–bromide mixture in acid medium, and after the reaction was judged to be complete, the unreacted bromine was determined iodometrically. The two spectrophotometricmethods are based on the bromination of the drug with a known excess of the bromate–bromide mixture under acidic conditions followed by the estimation of the surplus bromine by reaction with either Methyl Orange (Method B) or Indigo Carmine (Method C), and measuring the absorbance at 520 nm or 610 nm, respectively. In all the methods, the amount of reacted bromine corresponds to the drug content. The titrimetric procedure is applicable for between 6–15 mg and the reaction stoichiometry was found to be 1:1 (drug: BrO3-). The systems obey Beer’s law between 0.12 – 0.87 mgml-1 and 0.5 – 6.0 mgml-1 formethods B and C, respectively. The limits of detection and quantification are reported for both the spectrophotometricmethods. The methods could usefully be applied to routine quality control of pharmaceutical formulations containing FLD. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision. |
| first_indexed | 2024-12-20T12:49:04Z |
| format | Article |
| id | doaj.art-f1d712fea1b4462ea030b212a0b67460 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-20T12:49:04Z |
| publishDate | 2005-07-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-f1d712fea1b4462ea030b212a0b674602022-12-21T19:40:13ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392005-07-01707969978Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagentsKANAKAPURA BASAVAIAHUMAKANTHAPPA CHANDRASHEKARPAREGOWDA NAGE GOWDAThree new methods based on titrimetric and spectrophotometric techniques are described for the determination of felodipine (FLD) in the bulk drug and in tablets using a bromate–bromide mixture and two dyes, Methyl Orange and Indigo Carmine. In the titrimetric method (method A), the drug solution was treated with a measured excess of the bromate–bromide mixture in acid medium, and after the reaction was judged to be complete, the unreacted bromine was determined iodometrically. The two spectrophotometricmethods are based on the bromination of the drug with a known excess of the bromate–bromide mixture under acidic conditions followed by the estimation of the surplus bromine by reaction with either Methyl Orange (Method B) or Indigo Carmine (Method C), and measuring the absorbance at 520 nm or 610 nm, respectively. In all the methods, the amount of reacted bromine corresponds to the drug content. The titrimetric procedure is applicable for between 6–15 mg and the reaction stoichiometry was found to be 1:1 (drug: BrO3-). The systems obey Beer’s law between 0.12 – 0.87 mgml-1 and 0.5 – 6.0 mgml-1 formethods B and C, respectively. The limits of detection and quantification are reported for both the spectrophotometricmethods. The methods could usefully be applied to routine quality control of pharmaceutical formulations containing FLD. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.http://www.shd.org.yu/HtDocs/SHD/vol70/No7/JSCS_V70_No7-07.pdffelodipinebromate–bromidedeterminationMethyl OrangeIndigo Carmineformulations |
| spellingShingle | KANAKAPURA BASAVAIAH UMAKANTHAPPA CHANDRASHEKAR PAREGOWDA NAGE GOWDA Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents Journal of the Serbian Chemical Society felodipine bromate–bromide determination Methyl Orange Indigo Carmine formulations |
| title | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_full | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_fullStr | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_full_unstemmed | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_short | Titrimetric and spectrophotometric assay of felodipine in tablets using bromate–bromide, Methyl Orange and Indigo Carmine reagents |
| title_sort | titrimetric and spectrophotometric assay of felodipine in tablets using bromate bromide methyl orange and indigo carmine reagents |
| topic | felodipine bromate–bromide determination Methyl Orange Indigo Carmine formulations |
| url | http://www.shd.org.yu/HtDocs/SHD/vol70/No7/JSCS_V70_No7-07.pdf |
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