DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

Objectives: To characterize the impact of PCB exposure on DNA methylation in peripheral blood leucocytes and to evaluate the corresponding changes in relation to possible health effects, with a focus on B-cell lymphoma. Methods: We conducted an epigenome-wide association study on 611 adults free of...

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Main Authors: Panagiotis Georgiadis, Marios Gavriil, Panu Rantakokko, Efthymios Ladoukakis, Maria Botsivali, Rachel S. Kelly, Ingvar A. Bergdahl, Hannu Kiviranta, Roel C.H. Vermeulen, Florentin Spaeth, Dennie G.A.J. Hebbels, Jos C.S. Kleinjans, Theo M.C.M. de Kok, Domenico Palli, Paolo Vineis, Soterios A. Kyrtopoulos
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Environment International
Online Access:http://www.sciencedirect.com/science/article/pii/S0160412018325868

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