Pioneer Factor Improves CRISPR‐Based C‐To‐G and C‐To‐T Base Editing

Pioneer Factor Improves CRISPR‐Based C‐To‐G and C‐To‐T Base Editing

Abstract Base editing events in eukaryote require a compatible chromatin environment, but there is little research on how chromatin factors contribute to the editing efficiency or window. By engineering BEs (base editors) fused with various pioneer factors, the authors found that SOX2 substantially...

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Bibliographic Details
Main Authors: Chao Yang, Xingxiao Dong, Zhenzhen Ma, Bo Li, Changhao Bi, Xueli Zhang
Format: Article
Language:English
Published: Wiley 2022-09-01
Series:Advanced Science
Subjects:
CRISPR/Cas9
base editing
chromatin accessibility
pioneer factor
Online Access:https://doi.org/10.1002/advs.202202957

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