Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG).
<h4>Background</h4>Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some immunocompromised patients experience se...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-03-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012035&type=printable |
| _version_ | 1827572367757410304 |
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| author | Julia Kostka Anu S Maharjan Sanjai Kumar Douglas Hackenyos Peter J Krause Kevin Dieckhaus |
| author_facet | Julia Kostka Anu S Maharjan Sanjai Kumar Douglas Hackenyos Peter J Krause Kevin Dieckhaus |
| author_sort | Julia Kostka |
| collection | DOAJ |
| description | <h4>Background</h4>Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some immunocompromised patients experience severe acute and prolonged/relapsing illness due in part to an impaired host antibody response. Intravenous immunoglobulin (IVIG) has been used as an adjunctive therapy in some immunocompromised babesiosis patients, but its therapeutic effect is uncertain. We evaluated the presence of Babesia microti antibodies in commercial samples of IVIG.<h4>Methods/principle findings</h4>The presence of B. microti antibodies in commercial samples of IVIG were tested using an immunofluorescence assay. A subset of samples was then tested for B. microti antibodies using an enzyme linked immunosorbent assay. Out of 57 commercial IVIG samples tested using IFA, and 52 samples tested using ELISA, none were positive for B. microti antibodies.<h4>Conclusions</h4>Commercially available IVIG may not be of therapeutic benefit for babesiosis patients. Additional sampling of IVIG for B. microti antibody and a clinical trial of babesiosis patients given IVIG compared with controls would provide further insight into the use of IVIG for the treatment of babesiosis. |
| first_indexed | 2024-04-24T16:29:55Z |
| format | Article |
| id | doaj.art-f1d8bd596b084643acaf81c48b377bfe |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-04-24T16:29:55Z |
| publishDate | 2024-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-f1d8bd596b084643acaf81c48b377bfe2024-03-30T05:36:54ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352024-03-01183e001203510.1371/journal.pntd.0012035Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG).Julia KostkaAnu S MaharjanSanjai KumarDouglas HackenyosPeter J KrauseKevin Dieckhaus<h4>Background</h4>Babesiosis is a worldwide emerging protozoan infection that is associated with a spectrum of disease severity from asymptomatic infection to severe organ damage and death. While effective treatment strategies are available, some immunocompromised patients experience severe acute and prolonged/relapsing illness due in part to an impaired host antibody response. Intravenous immunoglobulin (IVIG) has been used as an adjunctive therapy in some immunocompromised babesiosis patients, but its therapeutic effect is uncertain. We evaluated the presence of Babesia microti antibodies in commercial samples of IVIG.<h4>Methods/principle findings</h4>The presence of B. microti antibodies in commercial samples of IVIG were tested using an immunofluorescence assay. A subset of samples was then tested for B. microti antibodies using an enzyme linked immunosorbent assay. Out of 57 commercial IVIG samples tested using IFA, and 52 samples tested using ELISA, none were positive for B. microti antibodies.<h4>Conclusions</h4>Commercially available IVIG may not be of therapeutic benefit for babesiosis patients. Additional sampling of IVIG for B. microti antibody and a clinical trial of babesiosis patients given IVIG compared with controls would provide further insight into the use of IVIG for the treatment of babesiosis.https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012035&type=printable |
| spellingShingle | Julia Kostka Anu S Maharjan Sanjai Kumar Douglas Hackenyos Peter J Krause Kevin Dieckhaus Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). PLoS Neglected Tropical Diseases |
| title | Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). |
| title_full | Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). |
| title_fullStr | Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). |
| title_full_unstemmed | Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). |
| title_short | Absence of Anti-Babesia microti antibody in commercial intravenous immunoglobulin (IVIG). |
| title_sort | absence of anti babesia microti antibody in commercial intravenous immunoglobulin ivig |
| url | https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0012035&type=printable |
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