Zinc carnosine: Frontiers advances of supplement for cancer therapy
Zinc (Zn) has an existence within large quantities in the human brain, while accumulating within synaptic vesicle. There is growing evidence that Zn metabolic equilibrium breaking participates into different diseases (e.g., vascular dementia, carcinoma, Alzheimer's disease). Carnosine refers to...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222005467 |
| _version_ | 1811255874530836480 |
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| author | Weiwei Tang Hanyuan Liu Theng Choon Ooi Nor Fadilah Rajab Hongyong Cao Razinah Sharif |
| author_facet | Weiwei Tang Hanyuan Liu Theng Choon Ooi Nor Fadilah Rajab Hongyong Cao Razinah Sharif |
| author_sort | Weiwei Tang |
| collection | DOAJ |
| description | Zinc (Zn) has an existence within large quantities in the human brain, while accumulating within synaptic vesicle. There is growing evidence that Zn metabolic equilibrium breaking participates into different diseases (e.g., vascular dementia, carcinoma, Alzheimer's disease). Carnosine refers to an endogenic dipeptide abundant in skeletal muscle and brains and exerts a variety of positive influences (e.g., carcinoma resistance, crosslinking resistance, metal chelation and oxidation limitation). A complex of Zn and carnosine, called Zinc-L-carnosine (ZnC), has been extensively employed within Zn supplement therapeutic method and the treating approach for ulcers. ZnC has been shown to play a variety of roles in the body, including inhibiting intracellular reactive oxygen species(ROS) and free radical levels, inhibiting inflammation, supplementing zinc enzymes and promoting wound healing and mucosal cell repair. The present study conducting a reviewing process for the advances of ZnC in tumor adjuvant therapy. |
| first_indexed | 2024-04-12T17:31:33Z |
| format | Article |
| id | doaj.art-f1d936ae09354bd896a40077e23ff73a |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-12T17:31:33Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f1d936ae09354bd896a40077e23ff73a2022-12-22T03:23:08ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-07-01151113157Zinc carnosine: Frontiers advances of supplement for cancer therapyWeiwei Tang0Hanyuan Liu1Theng Choon Ooi2Nor Fadilah Rajab3Hongyong Cao4Razinah Sharif5Center for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; Hepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Key Laboratory of Living Donor Transplantation, Chinese Academy of Medical Sciences, Nanjing, Jiangsu, ChinaGeneral Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaCenter for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, MalaysiaGeneral Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, ChinaCenter for Healthy Ageing & Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia; Biocompatibility Laboratory, Centre for Research and Instrumentation, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor Darul Ehsan, Malaysia; Corresponding author at: Center for Healthy Ageing & Wellness, Faculty of Health Sciences, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.Zinc (Zn) has an existence within large quantities in the human brain, while accumulating within synaptic vesicle. There is growing evidence that Zn metabolic equilibrium breaking participates into different diseases (e.g., vascular dementia, carcinoma, Alzheimer's disease). Carnosine refers to an endogenic dipeptide abundant in skeletal muscle and brains and exerts a variety of positive influences (e.g., carcinoma resistance, crosslinking resistance, metal chelation and oxidation limitation). A complex of Zn and carnosine, called Zinc-L-carnosine (ZnC), has been extensively employed within Zn supplement therapeutic method and the treating approach for ulcers. ZnC has been shown to play a variety of roles in the body, including inhibiting intracellular reactive oxygen species(ROS) and free radical levels, inhibiting inflammation, supplementing zinc enzymes and promoting wound healing and mucosal cell repair. The present study conducting a reviewing process for the advances of ZnC in tumor adjuvant therapy.http://www.sciencedirect.com/science/article/pii/S0753332222005467Zinc-L-carnosineCarcinomaSupplementAntioxidation |
| spellingShingle | Weiwei Tang Hanyuan Liu Theng Choon Ooi Nor Fadilah Rajab Hongyong Cao Razinah Sharif Zinc carnosine: Frontiers advances of supplement for cancer therapy Biomedicine & Pharmacotherapy Zinc-L-carnosine Carcinoma Supplement Antioxidation |
| title | Zinc carnosine: Frontiers advances of supplement for cancer therapy |
| title_full | Zinc carnosine: Frontiers advances of supplement for cancer therapy |
| title_fullStr | Zinc carnosine: Frontiers advances of supplement for cancer therapy |
| title_full_unstemmed | Zinc carnosine: Frontiers advances of supplement for cancer therapy |
| title_short | Zinc carnosine: Frontiers advances of supplement for cancer therapy |
| title_sort | zinc carnosine frontiers advances of supplement for cancer therapy |
| topic | Zinc-L-carnosine Carcinoma Supplement Antioxidation |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222005467 |
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