Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study
The Mediterranean (MED) diet was associated with a reduced risk of chronic disease, but the epidemiological studies reported inconsistent findings related to the MED diet and non-alcoholic fatty liver disease (NAFLD) risk. This age and the gender-matched case-control study were conducted among 247 a...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679021000434/type/journal_article |
| _version_ | 1811155956625571840 |
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| author | Mohammad-Reza Entezari Nasir Talenezhad Farhang Mirzavandi Shahab Rahimpour Hassan Mozaffari-Khosravi Hossein Fallahzadeh Mahdieh Hosseinzadeh |
| author_facet | Mohammad-Reza Entezari Nasir Talenezhad Farhang Mirzavandi Shahab Rahimpour Hassan Mozaffari-Khosravi Hossein Fallahzadeh Mahdieh Hosseinzadeh |
| author_sort | Mohammad-Reza Entezari |
| collection | DOAJ |
| description | The Mediterranean (MED) diet was associated with a reduced risk of chronic disease, but the epidemiological studies reported inconsistent findings related to the MED diet and non-alcoholic fatty liver disease (NAFLD) risk. This age and the gender-matched case-control study were conducted among 247 adult patients. The MED diet score was obtained based on the Trichopoulou model. Multivariate logistic regression was used to examine the association between the MED diet and NAFLD risk. NAFLD prevalence in people with low, moderate and high adherence to the MED diet was 33, 13⋅1 and 4⋅6 %, respectively. The increasing intake of the MED diet was significantly related to the increment intake of nuts and fruits, vegetables, monounsaturated fatty acid/polyunsaturated fatty acid ratio, legumes, cereals and fish. However, total energy consumption, low-fat dairy and meats intake were reduced (P for all < 0⋅05). Following control for age, the person in the highest of the MED diet tertile compared with the lowest, the odds of NAFLD decreased (OR: 0⋅40, 95 % CI: 0⋅17–0⋅95). This relation became a little stronger after further adjusting for sex, diabetes, physical activity and supplement intake (OR: 0⋅36, 95 % CI: 0⋅15–0⋅89). However, this association disappeared after adjusting for body mass index, waist and hip circumference (OR: 0⋅70, 95 % CI: 0⋅25–1⋅97). High adherence to the MED diet was associated with a 64 % reduction in NAFLD odds before some anthropometric variable adjustments. However, further prospective studies are required, particularly in BMI-stratified models. |
| first_indexed | 2024-04-10T04:43:29Z |
| format | Article |
| id | doaj.art-f1db7e54f3c142048538f3bce950dc02 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:29Z |
| publishDate | 2021-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-f1db7e54f3c142048538f3bce950dc022023-03-09T12:38:45ZengCambridge University PressJournal of Nutritional Science2048-67902021-01-011010.1017/jns.2021.43Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control studyMohammad-Reza Entezari0Nasir Talenezhad1Farhang Mirzavandi2Shahab Rahimpour3Hassan Mozaffari-Khosravi4Hossein Fallahzadeh5Mahdieh Hosseinzadeh6https://orcid.org/0000-0001-7482-2494Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranShahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranShahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranShahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranShahid Sadoughi University of Medical Sciences and Health Services, Yazd, IranDepartment of Biostatistics and Epidemiology, Research Center of Prevention and Epidemiology of Non-Communicable Disease, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranNutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, IranThe Mediterranean (MED) diet was associated with a reduced risk of chronic disease, but the epidemiological studies reported inconsistent findings related to the MED diet and non-alcoholic fatty liver disease (NAFLD) risk. This age and the gender-matched case-control study were conducted among 247 adult patients. The MED diet score was obtained based on the Trichopoulou model. Multivariate logistic regression was used to examine the association between the MED diet and NAFLD risk. NAFLD prevalence in people with low, moderate and high adherence to the MED diet was 33, 13⋅1 and 4⋅6 %, respectively. The increasing intake of the MED diet was significantly related to the increment intake of nuts and fruits, vegetables, monounsaturated fatty acid/polyunsaturated fatty acid ratio, legumes, cereals and fish. However, total energy consumption, low-fat dairy and meats intake were reduced (P for all < 0⋅05). Following control for age, the person in the highest of the MED diet tertile compared with the lowest, the odds of NAFLD decreased (OR: 0⋅40, 95 % CI: 0⋅17–0⋅95). This relation became a little stronger after further adjusting for sex, diabetes, physical activity and supplement intake (OR: 0⋅36, 95 % CI: 0⋅15–0⋅89). However, this association disappeared after adjusting for body mass index, waist and hip circumference (OR: 0⋅70, 95 % CI: 0⋅25–1⋅97). High adherence to the MED diet was associated with a 64 % reduction in NAFLD odds before some anthropometric variable adjustments. However, further prospective studies are required, particularly in BMI-stratified models.https://www.cambridge.org/core/product/identifier/S2048679021000434/type/journal_articleMediterranean dietNon-alcoholic fatty liver diseaseDietary pattern |
| spellingShingle | Mohammad-Reza Entezari Nasir Talenezhad Farhang Mirzavandi Shahab Rahimpour Hassan Mozaffari-Khosravi Hossein Fallahzadeh Mahdieh Hosseinzadeh Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study Journal of Nutritional Science Mediterranean diet Non-alcoholic fatty liver disease Dietary pattern |
| title | Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study |
| title_full | Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study |
| title_fullStr | Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study |
| title_full_unstemmed | Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study |
| title_short | Mediterranean dietary pattern and non-alcoholic fatty liver diseases: a case-control study |
| title_sort | mediterranean dietary pattern and non alcoholic fatty liver diseases a case control study |
| topic | Mediterranean diet Non-alcoholic fatty liver disease Dietary pattern |
| url | https://www.cambridge.org/core/product/identifier/S2048679021000434/type/journal_article |
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