Microfluidic Systems for Blood and Blood Cell Characterization
A laboratory blood test is vital for assessing a patient’s health and disease status. Advances in microfluidic technology have opened the door for on-chip blood analysis. Currently, microfluidic devices can reproduce myriad routine laboratory blood tests. Considerable progress has been made in micro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Biosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6374/13/1/13 |
| _version_ | 1797445438916263936 |
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| author | Hojin Kim Alexander Zhbanov Sung Yang |
| author_facet | Hojin Kim Alexander Zhbanov Sung Yang |
| author_sort | Hojin Kim |
| collection | DOAJ |
| description | A laboratory blood test is vital for assessing a patient’s health and disease status. Advances in microfluidic technology have opened the door for on-chip blood analysis. Currently, microfluidic devices can reproduce myriad routine laboratory blood tests. Considerable progress has been made in microfluidic cytometry, blood cell separation, and characterization. Along with the usual clinical parameters, microfluidics makes it possible to determine the physical properties of blood and blood cells. We review recent advances in microfluidic systems for measuring the physical properties and biophysical characteristics of blood and blood cells. Added emphasis is placed on multifunctional platforms that combine several microfluidic technologies for effective cell characterization. The combination of hydrodynamic, optical, electromagnetic, and/or acoustic methods in a microfluidic device facilitates the precise determination of various physical properties of blood and blood cells. We analyzed the physical quantities that are measured by microfluidic devices and the parameters that are determined through these measurements. We discuss unexplored problems and present our perspectives on the long-term challenges and trends associated with the application of microfluidics in clinical laboratories. We expect the characterization of the physical properties of blood and blood cells in a microfluidic environment to be considered a standard blood test in the future. |
| first_indexed | 2024-03-09T13:25:49Z |
| format | Article |
| id | doaj.art-f1dbc6ef81534ffea6f823bda0e83c34 |
| institution | Directory Open Access Journal |
| issn | 2079-6374 |
| language | English |
| last_indexed | 2024-03-09T13:25:49Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj.art-f1dbc6ef81534ffea6f823bda0e83c342023-11-30T21:24:13ZengMDPI AGBiosensors2079-63742022-12-011311310.3390/bios13010013Microfluidic Systems for Blood and Blood Cell CharacterizationHojin Kim0Alexander Zhbanov1Sung Yang2Department of Mechatronics Engineering, Dongseo University, Busan 47011, Republic of KoreaSchool of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of KoreaSchool of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of KoreaA laboratory blood test is vital for assessing a patient’s health and disease status. Advances in microfluidic technology have opened the door for on-chip blood analysis. Currently, microfluidic devices can reproduce myriad routine laboratory blood tests. Considerable progress has been made in microfluidic cytometry, blood cell separation, and characterization. Along with the usual clinical parameters, microfluidics makes it possible to determine the physical properties of blood and blood cells. We review recent advances in microfluidic systems for measuring the physical properties and biophysical characteristics of blood and blood cells. Added emphasis is placed on multifunctional platforms that combine several microfluidic technologies for effective cell characterization. The combination of hydrodynamic, optical, electromagnetic, and/or acoustic methods in a microfluidic device facilitates the precise determination of various physical properties of blood and blood cells. We analyzed the physical quantities that are measured by microfluidic devices and the parameters that are determined through these measurements. We discuss unexplored problems and present our perspectives on the long-term challenges and trends associated with the application of microfluidics in clinical laboratories. We expect the characterization of the physical properties of blood and blood cells in a microfluidic environment to be considered a standard blood test in the future.https://www.mdpi.com/2079-6374/13/1/13microfluidic systemsbloodblood cellsphysical propertiesbiophysical characteristics |
| spellingShingle | Hojin Kim Alexander Zhbanov Sung Yang Microfluidic Systems for Blood and Blood Cell Characterization Biosensors microfluidic systems blood blood cells physical properties biophysical characteristics |
| title | Microfluidic Systems for Blood and Blood Cell Characterization |
| title_full | Microfluidic Systems for Blood and Blood Cell Characterization |
| title_fullStr | Microfluidic Systems for Blood and Blood Cell Characterization |
| title_full_unstemmed | Microfluidic Systems for Blood and Blood Cell Characterization |
| title_short | Microfluidic Systems for Blood and Blood Cell Characterization |
| title_sort | microfluidic systems for blood and blood cell characterization |
| topic | microfluidic systems blood blood cells physical properties biophysical characteristics |
| url | https://www.mdpi.com/2079-6374/13/1/13 |
| work_keys_str_mv | AT hojinkim microfluidicsystemsforbloodandbloodcellcharacterization AT alexanderzhbanov microfluidicsystemsforbloodandbloodcellcharacterization AT sungyang microfluidicsystemsforbloodandbloodcellcharacterization |