DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation
RECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36968-1 |
| _version_ | 1797864320644677632 |
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| author | Xiaohua Xu Chou-Wei Chang Min Li Kenneth Omabe Nhung Le Yi-Hsuan Chen Feng Liang Yilun Liu |
| author_facet | Xiaohua Xu Chou-Wei Chang Min Li Kenneth Omabe Nhung Le Yi-Hsuan Chen Feng Liang Yilun Liu |
| author_sort | Xiaohua Xu |
| collection | DOAJ |
| description | RECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth. |
| first_indexed | 2024-04-09T22:51:00Z |
| format | Article |
| id | doaj.art-f1dc6d69f6634286b5147639209ee833 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:51:00Z |
| publishDate | 2023-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f1dc6d69f6634286b5147639209ee8332023-03-22T11:40:19ZengNature PortfolioNature Communications2041-17232023-03-0114111610.1038/s41467-023-36968-1DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiationXiaohua Xu0Chou-Wei Chang1Min Li2Kenneth Omabe3Nhung Le4Yi-Hsuan Chen5Feng Liang6Yilun Liu7Thermo Fisher ScientificVesigen TherapeuticsDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of HopeDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of HopeDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of HopeDepartment of Computer Science, University of Southern CaliforniaNeuroscience Graduate Program, University of Southern CaliforniaDepartment of Cancer Genetics and Epigenetics, Beckman Research Institute, City of HopeRECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.https://doi.org/10.1038/s41467-023-36968-1 |
| spellingShingle | Xiaohua Xu Chou-Wei Chang Min Li Kenneth Omabe Nhung Le Yi-Hsuan Chen Feng Liang Yilun Liu DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation Nature Communications |
| title | DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation |
| title_full | DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation |
| title_fullStr | DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation |
| title_full_unstemmed | DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation |
| title_short | DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation |
| title_sort | dna replication initiation factor recq4 possesses a role in antagonizing dna replication initiation |
| url | https://doi.org/10.1038/s41467-023-36968-1 |
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