A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A
Pediatric dermatoses constitute an array of varied diseases, a few of which may require long-term treatment with immunosuppressants in the form of corticosteroids (CS) and steroid-sparing agents such as azathioprine, cyclosporine, and methotrexate. There are numerous articles mentioning long-term ad...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Paediatric Dermatology |
| Subjects: | |
| Online Access: | http://www.ijpd.in/article.asp?issn=2319-7250;year=2022;volume=23;issue=3;spage=191;epage=203;aulast=Bose |
| _version_ | 1818194603718737920 |
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| author | Shiti Bose Bhushan Madke |
| author_facet | Shiti Bose Bhushan Madke |
| author_sort | Shiti Bose |
| collection | DOAJ |
| description | Pediatric dermatoses constitute an array of varied diseases, a few of which may require long-term treatment with immunosuppressants in the form of corticosteroids (CS) and steroid-sparing agents such as azathioprine, cyclosporine, and methotrexate. There are numerous articles mentioning long-term adverse effects of these immunosuppressants in adults, but just a few mentioning the same in the pediatric age group. This concise review focuses on the immunosuppressants commonly used for dermatoses in children and gives a comprehensive list of the various indications for use in each and associated adverse effect on long-term use. A comprehensive search was done using PubMed, Google, EMBASE, Cochrane, and MEDLINE on studies published till date on immunosuppressant use in pediatric dermatoses with special emphasis on the safety and adverse effects on long-term therapy. Only English language articles were considered. Thirty-eight articles were found, of which only 28 were selected after removing duplication and articles having no relevant information. Clinical as well as randomized double-blinded or single-blinded controlled trials, open-label studies, retrospective studies, case series, reviews, and case reports on the use of immunosuppressants in pediatric age group, including their long-term adverse effects were screened and a documented evidence was prepared, analyzed and presented in a narrative fashion to highlight the important pediatric indications for the use of the respective immunosuppressant, with special emphasis on the adverse effects on prolonged usage. The review has been divided into two parts for the reader's benefit. Part I consists of CS, azathioprine, and cyclosporine, whereas, Part II consists of methotrexate and mycophenolate mofetil. |
| first_indexed | 2024-12-12T01:04:55Z |
| format | Article |
| id | doaj.art-f1dd44d8b85d48bdbb348c5aafa5eca9 |
| institution | Directory Open Access Journal |
| issn | 2319-7250 |
| language | English |
| last_indexed | 2024-12-12T01:04:55Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Paediatric Dermatology |
| spelling | doaj.art-f1dd44d8b85d48bdbb348c5aafa5eca92022-12-22T00:43:36ZengWolters Kluwer Medknow PublicationsIndian Journal of Paediatric Dermatology2319-72502022-01-0123319120310.4103/ijpd.ijpd_83_21A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-AShiti BoseBhushan MadkePediatric dermatoses constitute an array of varied diseases, a few of which may require long-term treatment with immunosuppressants in the form of corticosteroids (CS) and steroid-sparing agents such as azathioprine, cyclosporine, and methotrexate. There are numerous articles mentioning long-term adverse effects of these immunosuppressants in adults, but just a few mentioning the same in the pediatric age group. This concise review focuses on the immunosuppressants commonly used for dermatoses in children and gives a comprehensive list of the various indications for use in each and associated adverse effect on long-term use. A comprehensive search was done using PubMed, Google, EMBASE, Cochrane, and MEDLINE on studies published till date on immunosuppressant use in pediatric dermatoses with special emphasis on the safety and adverse effects on long-term therapy. Only English language articles were considered. Thirty-eight articles were found, of which only 28 were selected after removing duplication and articles having no relevant information. Clinical as well as randomized double-blinded or single-blinded controlled trials, open-label studies, retrospective studies, case series, reviews, and case reports on the use of immunosuppressants in pediatric age group, including their long-term adverse effects were screened and a documented evidence was prepared, analyzed and presented in a narrative fashion to highlight the important pediatric indications for the use of the respective immunosuppressant, with special emphasis on the adverse effects on prolonged usage. The review has been divided into two parts for the reader's benefit. Part I consists of CS, azathioprine, and cyclosporine, whereas, Part II consists of methotrexate and mycophenolate mofetil.http://www.ijpd.in/article.asp?issn=2319-7250;year=2022;volume=23;issue=3;spage=191;epage=203;aulast=Boseadverse effectsimmunosuppressantslong-term usepediatric dermatosessteroid sparing |
| spellingShingle | Shiti Bose Bhushan Madke A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A Indian Journal of Paediatric Dermatology adverse effects immunosuppressants long-term use pediatric dermatoses steroid sparing |
| title | A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A |
| title_full | A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A |
| title_fullStr | A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A |
| title_full_unstemmed | A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A |
| title_short | A comprehensive review of immunosuppressive drugs in pediatric dermatoses: Part I - Corticosteroids, azathioprine, and cyclosporine-A |
| title_sort | comprehensive review of immunosuppressive drugs in pediatric dermatoses part i corticosteroids azathioprine and cyclosporine a |
| topic | adverse effects immunosuppressants long-term use pediatric dermatoses steroid sparing |
| url | http://www.ijpd.in/article.asp?issn=2319-7250;year=2022;volume=23;issue=3;spage=191;epage=203;aulast=Bose |
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