Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological d...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-06-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/3/6/1812/ |
| _version_ | 1818359832366809088 |
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| author | Amy H. Moore Matthew J. Bigbee Grace E. Boynton Colin M. Wakeham Hilary M. Rosenheim Christopher J. Staral James L. Morrissey Amanda K. Hund |
| author_facet | Amy H. Moore Matthew J. Bigbee Grace E. Boynton Colin M. Wakeham Hilary M. Rosenheim Christopher J. Staral James L. Morrissey Amanda K. Hund |
| author_sort | Amy H. Moore |
| collection | DOAJ |
| description | Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses, and clinical trials. |
| first_indexed | 2024-12-13T20:51:10Z |
| format | Article |
| id | doaj.art-f1dda3d5997a4f05ab8f449ebd2d0946 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-13T20:51:10Z |
| publishDate | 2010-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-f1dda3d5997a4f05ab8f449ebd2d09462022-12-21T23:31:52ZengMDPI AGPharmaceuticals1424-82472010-06-01361812184110.3390/ph3061812Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of NeuroinflammationAmy H. MooreMatthew J. BigbeeGrace E. BoyntonColin M. WakehamHilary M. RosenheimChristopher J. StaralJames L. MorrisseyAmanda K. HundAlzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative diseases with age as the greatest risk factor. As the general population experiences extended life span, preparation for the prevention and treatment of these and other age-associated neurological diseases are warranted. Since epidemiological studies suggested that non-steroidal anti-inflammatory drug (NSAID) use decreased risk for AD and PD, increasing attention has been devoted to understanding the costs and benefits of the innate neuroinflammatory response to functional recovery following pathology onset. This review will provide a general overview on the role of neuroinflammation in these neurodegenerative diseases and an update on NSAID treatment in recent experimental animal models, epidemiological analyses, and clinical trials.http://www.mdpi.com/1424-8247/3/6/1812/Non-steroidal anti-inflammatory drugsAlzheimer's diseaseParkinson's diseasecyclooxygenaseneuroinflammation |
| spellingShingle | Amy H. Moore Matthew J. Bigbee Grace E. Boynton Colin M. Wakeham Hilary M. Rosenheim Christopher J. Staral James L. Morrissey Amanda K. Hund Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation Pharmaceuticals Non-steroidal anti-inflammatory drugs Alzheimer's disease Parkinson's disease cyclooxygenase neuroinflammation |
| title | Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation |
| title_full | Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation |
| title_fullStr | Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation |
| title_full_unstemmed | Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation |
| title_short | Non-Steroidal Anti-Inflammatory Drugs in Alzheimer's Disease and Parkinson's Disease: Reconsidering the Role of Neuroinflammation |
| title_sort | non steroidal anti inflammatory drugs in alzheimer s disease and parkinson s disease reconsidering the role of neuroinflammation |
| topic | Non-steroidal anti-inflammatory drugs Alzheimer's disease Parkinson's disease cyclooxygenase neuroinflammation |
| url | http://www.mdpi.com/1424-8247/3/6/1812/ |
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