Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease
Background Recent studies have reported the association between pericoronary inflammation assessed by pericoronary adipose tissue attenuation (PCATA) on computed tomography angiography and worse outcomes in patients with coronary artery disease. We investigated the determinants predicting increased...
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| Language: | English |
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Wiley
2020-08-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.016202 |
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| author | Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hoshino Masao Yamaguchi Masahiro Hada Hiroaki Ohya Yohei Sumino Hidenori Hirano Yoshinori Kanno Tomoki Horie Toru Misawa Kai Nogami Hiroki Ueno Rikuta Hamaya Eisuke Usui Tadashi Murai Tetsumin Lee Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta |
| author_facet | Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hoshino Masao Yamaguchi Masahiro Hada Hiroaki Ohya Yohei Sumino Hidenori Hirano Yoshinori Kanno Tomoki Horie Toru Misawa Kai Nogami Hiroki Ueno Rikuta Hamaya Eisuke Usui Tadashi Murai Tetsumin Lee Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta |
| author_sort | Tomoyo Sugiyama |
| collection | DOAJ |
| description | Background Recent studies have reported the association between pericoronary inflammation assessed by pericoronary adipose tissue attenuation (PCATA) on computed tomography angiography and worse outcomes in patients with coronary artery disease. We investigated the determinants predicting increased PCATA in patients with known or suspected coronary artery disease. Methods and Results A total of 540 patients who underwent computed tomography angiography and invasive coronary angiography were studied. Mean computed tomography attenuation values of PCAT (−190 to −30 Hounsfield units) (PCATA) were assessed at the proximal 40‐mm segments of all 3 major coronary arteries by crude analysis. Univariable and multivariable analyses were performed to determine the predictors of increased PCATA surrounding the proximal right coronary artery. Mean right coronary artery‐PCATA was −72.22±8.47 Hounsfield units and the average of 3‐vessel PCATA was −70.24±6.60 Hounsfield units. Multivariable linear regression analysis revealed that the independent determinants of right coronary artery‐PCATA were male (β coefficient=4.965, P<0.001), left ventricular mass index (β coefficient=0.040, P=0.025), and angiographically significant stenosis (diameter stenosis >50%) (β coefficient=2.418, P=0.008). Sex‐related determinants were NT‐proBNP level (N‐terminal pro‐B‐type natriuretic peptide; β coefficient <0.001, P=0.026), Agatston score (β coefficient=−0.002, P=0.010), left ventricular mass index (β coefficient=0.041, P=0.028), and significant stenosis (β coefficient=4.006, P<0.001) in male patients and left ventricular ejection fraction (β coefficient=−0.217, P=0.010) and significant stenosis (β coefficient=3.835, P=0.023) in female patients. Conclusions Right coronary artery‐PCATA was associated with multiple clinical characteristics, established risk factors, and the presence of significant stenosis. Our results suggest that clinically significant factors such as sex, left ventricular hypertrophy, ejection fraction, calcification, and epicardial stenosis should be taken into account in the assessment of pericoronary inflammation using computed tomography angiography. |
| first_indexed | 2024-04-13T16:36:45Z |
| format | Article |
| id | doaj.art-f1de733c6c6a493b8e08cf5bdb5518b9 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:36:45Z |
| publishDate | 2020-08-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-f1de733c6c6a493b8e08cf5bdb5518b92022-12-22T02:39:25ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802020-08-0191510.1161/JAHA.120.016202Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery DiseaseTomoyo Sugiyama0Yoshihisa Kanaji1Masahiro Hoshino2Masao Yamaguchi3Masahiro Hada4Hiroaki Ohya5Yohei Sumino6Hidenori Hirano7Yoshinori Kanno8Tomoki Horie9Toru Misawa10Kai Nogami11Hiroki Ueno12Rikuta Hamaya13Eisuke Usui14Tadashi Murai15Tetsumin Lee16Taishi Yonetsu17Tetsuo Sasano18Tsunekazu Kakuta19Department of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanDepartment of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo JapanDepartment of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo JapanDepartment of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo JapanDepartment of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki JapanBackground Recent studies have reported the association between pericoronary inflammation assessed by pericoronary adipose tissue attenuation (PCATA) on computed tomography angiography and worse outcomes in patients with coronary artery disease. We investigated the determinants predicting increased PCATA in patients with known or suspected coronary artery disease. Methods and Results A total of 540 patients who underwent computed tomography angiography and invasive coronary angiography were studied. Mean computed tomography attenuation values of PCAT (−190 to −30 Hounsfield units) (PCATA) were assessed at the proximal 40‐mm segments of all 3 major coronary arteries by crude analysis. Univariable and multivariable analyses were performed to determine the predictors of increased PCATA surrounding the proximal right coronary artery. Mean right coronary artery‐PCATA was −72.22±8.47 Hounsfield units and the average of 3‐vessel PCATA was −70.24±6.60 Hounsfield units. Multivariable linear regression analysis revealed that the independent determinants of right coronary artery‐PCATA were male (β coefficient=4.965, P<0.001), left ventricular mass index (β coefficient=0.040, P=0.025), and angiographically significant stenosis (diameter stenosis >50%) (β coefficient=2.418, P=0.008). Sex‐related determinants were NT‐proBNP level (N‐terminal pro‐B‐type natriuretic peptide; β coefficient <0.001, P=0.026), Agatston score (β coefficient=−0.002, P=0.010), left ventricular mass index (β coefficient=0.041, P=0.028), and significant stenosis (β coefficient=4.006, P<0.001) in male patients and left ventricular ejection fraction (β coefficient=−0.217, P=0.010) and significant stenosis (β coefficient=3.835, P=0.023) in female patients. Conclusions Right coronary artery‐PCATA was associated with multiple clinical characteristics, established risk factors, and the presence of significant stenosis. Our results suggest that clinically significant factors such as sex, left ventricular hypertrophy, ejection fraction, calcification, and epicardial stenosis should be taken into account in the assessment of pericoronary inflammation using computed tomography angiography.https://www.ahajournals.org/doi/10.1161/JAHA.120.016202adipose tissuecomputed tomography angiographycoronary artery diseaseinflammation |
| spellingShingle | Tomoyo Sugiyama Yoshihisa Kanaji Masahiro Hoshino Masao Yamaguchi Masahiro Hada Hiroaki Ohya Yohei Sumino Hidenori Hirano Yoshinori Kanno Tomoki Horie Toru Misawa Kai Nogami Hiroki Ueno Rikuta Hamaya Eisuke Usui Tadashi Murai Tetsumin Lee Taishi Yonetsu Tetsuo Sasano Tsunekazu Kakuta Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease adipose tissue computed tomography angiography coronary artery disease inflammation |
| title | Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease |
| title_full | Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease |
| title_fullStr | Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease |
| title_full_unstemmed | Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease |
| title_short | Determinants of Pericoronary Adipose Tissue Attenuation on Computed Tomography Angiography in Coronary Artery Disease |
| title_sort | determinants of pericoronary adipose tissue attenuation on computed tomography angiography in coronary artery disease |
| topic | adipose tissue computed tomography angiography coronary artery disease inflammation |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.016202 |
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