Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis
Abstract Background Electroconvulsive therapy (ECT) endures as a definitive treatment for refractory depression and catatonia and is also considered an effective treatment for a number of other severe psychiatric disorders (Lisanby, N Engl J Med 357:1939-1945, 2007)(Weiner and Prudic, Biol Psychiatr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Journal of Anesthesia, Analgesia and Critical Care |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s44158-024-00143-9 |
| _version_ | 1797272862361387008 |
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| author | Houman Amirfarzan Kaitlin Jane Cassidy Mehrak Moaddab Ma Demin Roman Schumann Bradford Lewis |
| author_facet | Houman Amirfarzan Kaitlin Jane Cassidy Mehrak Moaddab Ma Demin Roman Schumann Bradford Lewis |
| author_sort | Houman Amirfarzan |
| collection | DOAJ |
| description | Abstract Background Electroconvulsive therapy (ECT) endures as a definitive treatment for refractory depression and catatonia and is also considered an effective treatment for a number of other severe psychiatric disorders (Lisanby, N Engl J Med 357:1939-1945, 2007)(Weiner and Prudic, Biol Psychiatry 73:105-106, 2013). GA is an essential component of the ECT procedure for various reasons (Lee, Jenkins and Sparkle, Life 11, 2021). Monitoring anesthetic effects on the brain is desirable as anesthetic agents affect seizure duration and recovery (Rasulo, Hopkins, Lobo, et al, Neurocrit Care 38:296-311, 2023) (Jones , Nittur , Fleming and Applegate, BMC Anesthesiol 21:105, 2021) (Soehle , Kayser , Ellerkmann and Schlaepfer, BJA 112:695-702, 2013). Perioperative anesthetic effects on consciousness can be assessed with brain function monitoring using raw electroencephalogram (EEG) traces and processed EEG indices. Objective We examined the usefulness and utility of the SedLine® anesthetic effect monitor during ECT procedures. We hypothesized that the seizure duration as measured by the EEG tracing of the ECT machine is equivalent to the duration assessed by the SedLine® EEG tracing. A secondary objective was to describe the SedLine® patient state indices (PSI) at different phases of treatment. Methods Following IRB approval, we analyzed the data of the electronic medical records of 45 ECT treatments of 23 patients in an urban VA medical center between July 01, 2021, and March 30, 2022. We compared the seizure duration in minutes and seconds as measured either by the ECT machine EEG tracing or the SedLine® EEG tracing. We then collected SedLine® processed EEG indices at four different stages during the treatment. Appropriate comparative and observational statistical analyses were applied. Results There was no significant difference in measured seizure duration between the two methods examined (p < 0.05). We observed a lag of the SedLine PSI value at the time before stimulus delivery and limited PSI utility during the course of ECT. Conclusion The SedLine® EEG tracing can be an alternative to the machine EEG tracing for the determination of seizure duration. The SedLine® processed EEG indices are not consistently useful before and after ECT delivery. Anesthetic effect monitoring during ECT is feasible. |
| first_indexed | 2024-03-07T14:35:25Z |
| format | Article |
| id | doaj.art-f1df7f3f268344cbb15f3dc365870003 |
| institution | Directory Open Access Journal |
| issn | 2731-3786 |
| language | English |
| last_indexed | 2024-03-07T14:35:25Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Anesthesia, Analgesia and Critical Care |
| spelling | doaj.art-f1df7f3f268344cbb15f3dc3658700032024-03-05T20:41:53ZengBMCJournal of Anesthesia, Analgesia and Critical Care2731-37862024-02-01411710.1186/s44158-024-00143-9Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysisHouman Amirfarzan0Kaitlin Jane Cassidy1Mehrak Moaddab2Ma Demin3Roman Schumann4Bradford Lewis5Department of Anesthesia, Critical Care and Pain Medicine, VA Boston Healthcare System, Tufts University School of MedicineCooperative Studies Program Clinical Trials Coordinating Center, VA Boston Healthcare SystemDepartment of Anesthesia, Critical Care and Pain Medicine, Tufts Medical Center, Tufts University School of MedicineDepartment of Psychiatry, VA Boston Healthcare System, Harvard Medical SchoolDepartment of Anesthesia, Critical Care and Pain Medicine, VA Boston Healthcare System, Tufts University School of MedicineDepartment of Psychiatry, VA Boston Healthcare System, Harvard Medical SchoolAbstract Background Electroconvulsive therapy (ECT) endures as a definitive treatment for refractory depression and catatonia and is also considered an effective treatment for a number of other severe psychiatric disorders (Lisanby, N Engl J Med 357:1939-1945, 2007)(Weiner and Prudic, Biol Psychiatry 73:105-106, 2013). GA is an essential component of the ECT procedure for various reasons (Lee, Jenkins and Sparkle, Life 11, 2021). Monitoring anesthetic effects on the brain is desirable as anesthetic agents affect seizure duration and recovery (Rasulo, Hopkins, Lobo, et al, Neurocrit Care 38:296-311, 2023) (Jones , Nittur , Fleming and Applegate, BMC Anesthesiol 21:105, 2021) (Soehle , Kayser , Ellerkmann and Schlaepfer, BJA 112:695-702, 2013). Perioperative anesthetic effects on consciousness can be assessed with brain function monitoring using raw electroencephalogram (EEG) traces and processed EEG indices. Objective We examined the usefulness and utility of the SedLine® anesthetic effect monitor during ECT procedures. We hypothesized that the seizure duration as measured by the EEG tracing of the ECT machine is equivalent to the duration assessed by the SedLine® EEG tracing. A secondary objective was to describe the SedLine® patient state indices (PSI) at different phases of treatment. Methods Following IRB approval, we analyzed the data of the electronic medical records of 45 ECT treatments of 23 patients in an urban VA medical center between July 01, 2021, and March 30, 2022. We compared the seizure duration in minutes and seconds as measured either by the ECT machine EEG tracing or the SedLine® EEG tracing. We then collected SedLine® processed EEG indices at four different stages during the treatment. Appropriate comparative and observational statistical analyses were applied. Results There was no significant difference in measured seizure duration between the two methods examined (p < 0.05). We observed a lag of the SedLine PSI value at the time before stimulus delivery and limited PSI utility during the course of ECT. Conclusion The SedLine® EEG tracing can be an alternative to the machine EEG tracing for the determination of seizure duration. The SedLine® processed EEG indices are not consistently useful before and after ECT delivery. Anesthetic effect monitoring during ECT is feasible.https://doi.org/10.1186/s44158-024-00143-9Anesthetic IVMethohexitalElectroconvulsive therapyProcessed EEGDepth of anesthesiaSedLine® |
| spellingShingle | Houman Amirfarzan Kaitlin Jane Cassidy Mehrak Moaddab Ma Demin Roman Schumann Bradford Lewis Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis Journal of Anesthesia, Analgesia and Critical Care Anesthetic IV Methohexital Electroconvulsive therapy Processed EEG Depth of anesthesia SedLine® |
| title | Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis |
| title_full | Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis |
| title_fullStr | Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis |
| title_full_unstemmed | Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis |
| title_short | Assessment of seizure duration and utility of using SedLine® EEG tracing in veterans undergoing electroconvulsive therapy: a retrospective analysis |
| title_sort | assessment of seizure duration and utility of using sedline r eeg tracing in veterans undergoing electroconvulsive therapy a retrospective analysis |
| topic | Anesthetic IV Methohexital Electroconvulsive therapy Processed EEG Depth of anesthesia SedLine® |
| url | https://doi.org/10.1186/s44158-024-00143-9 |
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