Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis
Taurine, an abundant free amino acid, plays multiple roles in the body, including bile acid conjugation, osmoregulation, oxidative stress, and inflammation prevention. Although the relationship between taurine and the gut has been briefly described, the effects of taurine on the reconstitution of in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/4/1048 |
| _version_ | 1797606322596741120 |
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| author | Weike Qian Mingyang Li Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai |
| author_facet | Weike Qian Mingyang Li Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai |
| author_sort | Weike Qian |
| collection | DOAJ |
| description | Taurine, an abundant free amino acid, plays multiple roles in the body, including bile acid conjugation, osmoregulation, oxidative stress, and inflammation prevention. Although the relationship between taurine and the gut has been briefly described, the effects of taurine on the reconstitution of intestinal flora homeostasis under conditions of gut dysbiosis and underlying mechanisms remain unclear. This study examined the effects of taurine on the intestinal flora and homeostasis of healthy mice and mice with dysbiosis caused by antibiotic treatment and pathogenic bacterial infections. The results showed that taurine supplementation could significantly regulate intestinal microflora, alter fecal bile acid composition, reverse the decrease in <i>Lactobacillus</i> abundance, boost intestinal immunity in response to antibiotic exposure, resist colonization by <i>Citrobacter rodentium</i>, and enhance the diversity of flora during infection. Our results indicate that taurine has the potential to shape the gut microbiota of mice and positively affect the restoration of intestinal homeostasis. Thus, taurine can be utilized as a targeted regulator to re-establish a normal microenvironment and to treat or prevent gut dysbiosis. |
| first_indexed | 2024-03-11T05:13:35Z |
| format | Article |
| id | doaj.art-f1e024467380449c91b4c69b6678b511 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T05:13:35Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-f1e024467380449c91b4c69b6678b5112023-11-17T18:25:48ZengMDPI AGBiomedicines2227-90592023-03-01114104810.3390/biomedicines11041048Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut DysbiosisWeike Qian0Mingyang Li1Leilei Yu2Fengwei Tian3Jianxin Zhao4Qixiao Zhai5State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, ChinaTaurine, an abundant free amino acid, plays multiple roles in the body, including bile acid conjugation, osmoregulation, oxidative stress, and inflammation prevention. Although the relationship between taurine and the gut has been briefly described, the effects of taurine on the reconstitution of intestinal flora homeostasis under conditions of gut dysbiosis and underlying mechanisms remain unclear. This study examined the effects of taurine on the intestinal flora and homeostasis of healthy mice and mice with dysbiosis caused by antibiotic treatment and pathogenic bacterial infections. The results showed that taurine supplementation could significantly regulate intestinal microflora, alter fecal bile acid composition, reverse the decrease in <i>Lactobacillus</i> abundance, boost intestinal immunity in response to antibiotic exposure, resist colonization by <i>Citrobacter rodentium</i>, and enhance the diversity of flora during infection. Our results indicate that taurine has the potential to shape the gut microbiota of mice and positively affect the restoration of intestinal homeostasis. Thus, taurine can be utilized as a targeted regulator to re-establish a normal microenvironment and to treat or prevent gut dysbiosis.https://www.mdpi.com/2227-9059/11/4/1048taurinegut microbiotadysbiosisantibiontic<i>Citrobacter rodentium</i> |
| spellingShingle | Weike Qian Mingyang Li Leilei Yu Fengwei Tian Jianxin Zhao Qixiao Zhai Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis Biomedicines taurine gut microbiota dysbiosis antibiontic <i>Citrobacter rodentium</i> |
| title | Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis |
| title_full | Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis |
| title_fullStr | Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis |
| title_full_unstemmed | Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis |
| title_short | Effects of Taurine on Gut Microbiota Homeostasis: An Evaluation Based on Two Models of Gut Dysbiosis |
| title_sort | effects of taurine on gut microbiota homeostasis an evaluation based on two models of gut dysbiosis |
| topic | taurine gut microbiota dysbiosis antibiontic <i>Citrobacter rodentium</i> |
| url | https://www.mdpi.com/2227-9059/11/4/1048 |
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