Evaluation of HS-CRP and Lipid Profile in COPD
Introduction: COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2943/4-%205187_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP)_U(PP)_FPF2(PP).pdf |
| Summary: | Introduction: COPD is a major public health problem. More than
50 % of the patients of COPD die because of some cardiovascular
event. Traditionally, the risk of CVD is assessed by the presence
of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk
factor for the CVD assessment. In this study, we assessed the
patients of COPD for CVD with HS-CRP and lipid indicators.
Material and Methods: Forty Five diagnosed patients of COPD
and 45 age, sex, and BMI matched healthy controls were enrolled
for the study after the institutional ethical committee’s clearance
was obtained. The fasting serum samples of the study subjects
were evaluated for the lipid profile and HS-CRP.
Results: There was no statistical difference in the lipid profile
in the two groups, while HS-CRP was significantly raised in
the COPD patients. On applying kappa statistics, we found a
poor agreement between the lipid parameters and HS-CRP in
estimating the risk for CVD. This underlines the independent
importance of HS-CRP in the CVD assessment of COPD
patients.
Discussion: GOLD has described COPD as a systemic chronic
inflammatory disease which involves the lung and the distant
organs by the emissary of the systemic inflammation, which is also
an antecedent to cardiovascular diseases. COPD is a systemic
inflammatory disease which is underlined by this study. But the
derangement of the lipid indicators is not statistically significant.
This suggests the addition of HS-CRP in the assessment of the
COPD patients for CVD. This further needs to be ascertained in
a large prospective model.
Conclusion: COPD is systemic inflammatory disease, but there
is hardly any derangement of the lipid indicators. |
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| ISSN: | 2249-782X 0973-709X |