Evaluation of HS-CRP and Lipid Profile in COPD
Introduction: COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2013-05-01
|
| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/2943/4-%205187_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP)_U(PP)_FPF2(PP).pdf |
| _version_ | 1818456439888281600 |
|---|---|
| author | Anup N. Nillawar Kedar B. Joshi Sandip Bharat Patil Jayshree S. Bardapurkar Suhas J. Bardapurkar |
| author_facet | Anup N. Nillawar Kedar B. Joshi Sandip Bharat Patil Jayshree S. Bardapurkar Suhas J. Bardapurkar |
| author_sort | Anup N. Nillawar |
| collection | DOAJ |
| description | Introduction: COPD is a major public health problem. More than
50 % of the patients of COPD die because of some cardiovascular
event. Traditionally, the risk of CVD is assessed by the presence
of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk
factor for the CVD assessment. In this study, we assessed the
patients of COPD for CVD with HS-CRP and lipid indicators.
Material and Methods: Forty Five diagnosed patients of COPD
and 45 age, sex, and BMI matched healthy controls were enrolled
for the study after the institutional ethical committee’s clearance
was obtained. The fasting serum samples of the study subjects
were evaluated for the lipid profile and HS-CRP.
Results: There was no statistical difference in the lipid profile
in the two groups, while HS-CRP was significantly raised in
the COPD patients. On applying kappa statistics, we found a
poor agreement between the lipid parameters and HS-CRP in
estimating the risk for CVD. This underlines the independent
importance of HS-CRP in the CVD assessment of COPD
patients.
Discussion: GOLD has described COPD as a systemic chronic
inflammatory disease which involves the lung and the distant
organs by the emissary of the systemic inflammation, which is also
an antecedent to cardiovascular diseases. COPD is a systemic
inflammatory disease which is underlined by this study. But the
derangement of the lipid indicators is not statistically significant.
This suggests the addition of HS-CRP in the assessment of the
COPD patients for CVD. This further needs to be ascertained in
a large prospective model.
Conclusion: COPD is systemic inflammatory disease, but there
is hardly any derangement of the lipid indicators. |
| first_indexed | 2024-12-14T22:26:42Z |
| format | Article |
| id | doaj.art-f1e2d2f65a86468592e44dc54c5758cd |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T22:26:42Z |
| publishDate | 2013-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-f1e2d2f65a86468592e44dc54c5758cd2022-12-21T22:45:21ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2013-05-017580180310.7860/JCDR/2013/5187.2943Evaluation of HS-CRP and Lipid Profile in COPDAnup N. Nillawar0Kedar B. Joshi1Sandip Bharat Patil2Jayshree S. Bardapurkar3Suhas J. Bardapurkar4Associate Professor, Department of Biochemistry, SBKS Medical College, Vadodara, Gujarat, India.Assistant Professor, Department of Biochemistry, GMC, Aurangabad, India.Assistant Professor, Department of Preventive and Social Medicine, Chirayu Medical College and Hospital, Bhopal, India.Professor, Department of Biochemistry, SIMS, Haapur, UP, India.Consultant, Department of Medicine, Shree Nursing Home, Aurangabad, India.Introduction: COPD is a major public health problem. More than 50 % of the patients of COPD die because of some cardiovascular event. Traditionally, the risk of CVD is assessed by the presence of dyslipidaemia. Recently, HS-CRP has emerged as a novel risk factor for the CVD assessment. In this study, we assessed the patients of COPD for CVD with HS-CRP and lipid indicators. Material and Methods: Forty Five diagnosed patients of COPD and 45 age, sex, and BMI matched healthy controls were enrolled for the study after the institutional ethical committee’s clearance was obtained. The fasting serum samples of the study subjects were evaluated for the lipid profile and HS-CRP. Results: There was no statistical difference in the lipid profile in the two groups, while HS-CRP was significantly raised in the COPD patients. On applying kappa statistics, we found a poor agreement between the lipid parameters and HS-CRP in estimating the risk for CVD. This underlines the independent importance of HS-CRP in the CVD assessment of COPD patients. Discussion: GOLD has described COPD as a systemic chronic inflammatory disease which involves the lung and the distant organs by the emissary of the systemic inflammation, which is also an antecedent to cardiovascular diseases. COPD is a systemic inflammatory disease which is underlined by this study. But the derangement of the lipid indicators is not statistically significant. This suggests the addition of HS-CRP in the assessment of the COPD patients for CVD. This further needs to be ascertained in a large prospective model. Conclusion: COPD is systemic inflammatory disease, but there is hardly any derangement of the lipid indicators.https://jcdr.net/articles/PDF/2943/4-%205187_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP)_U(PP)_FPF2(PP).pdfcopdhs-crplipid profilesystemic inflammation |
| spellingShingle | Anup N. Nillawar Kedar B. Joshi Sandip Bharat Patil Jayshree S. Bardapurkar Suhas J. Bardapurkar Evaluation of HS-CRP and Lipid Profile in COPD Journal of Clinical and Diagnostic Research copd hs-crp lipid profile systemic inflammation |
| title | Evaluation of HS-CRP and Lipid Profile in COPD |
| title_full | Evaluation of HS-CRP and Lipid Profile in COPD |
| title_fullStr | Evaluation of HS-CRP and Lipid Profile in COPD |
| title_full_unstemmed | Evaluation of HS-CRP and Lipid Profile in COPD |
| title_short | Evaluation of HS-CRP and Lipid Profile in COPD |
| title_sort | evaluation of hs crp and lipid profile in copd |
| topic | copd hs-crp lipid profile systemic inflammation |
| url | https://jcdr.net/articles/PDF/2943/4-%205187_PF1(M)_E(C)_F(T)_PF1(M)_PF1(T)_FA(T)_PF1(PP)_U(PP)_FPF2(PP).pdf |
| work_keys_str_mv | AT anupnnillawar evaluationofhscrpandlipidprofileincopd AT kedarbjoshi evaluationofhscrpandlipidprofileincopd AT sandipbharatpatil evaluationofhscrpandlipidprofileincopd AT jayshreesbardapurkar evaluationofhscrpandlipidprofileincopd AT suhasjbardapurkar evaluationofhscrpandlipidprofileincopd |