The mechanism of nickel-induced autophagy and its role in nephrotoxicity

The mechanism of nickel-induced autophagy and its role in nephrotoxicity

Nickel (Ni), an environmental health hazard, is nephrotoxic to humans, but the exact mechanism is unknown. This study aims to identify whether nephrotoxicity is associated with autophagy. Here, nickel chloride (NiCl2) increased autophagy in TCMK-1 cells. NiCl2 induces autophagy through Akt and AMPK/...

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Bibliographic Details
Main Authors: Heng Yin, Chengbi Wang, Hongrui Guo, Xiaocong Li, Jingbo Liu
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Nickel
Kidney
Autophagy
Mitophagy
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651324002252

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