Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery
In this work, dasatinib (DAS) nanoemulsion and nanocrystal are produced by high-gravity technology that approaches to practical mass production. The drug nanoformulations were systematically characterized and evaluated. At a low high-gravity level (β) = 47, nanoemulsion droplets were 16.15 ± 0.42 nm...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/1/197 |
| _version_ | 1797491110658965504 |
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| author | Chuanqi Wang Manting Wang Peng Chen Jiexin Wang Yuan Le |
| author_facet | Chuanqi Wang Manting Wang Peng Chen Jiexin Wang Yuan Le |
| author_sort | Chuanqi Wang |
| collection | DOAJ |
| description | In this work, dasatinib (DAS) nanoemulsion and nanocrystal are produced by high-gravity technology that approaches to practical mass production. The drug nanoformulations were systematically characterized and evaluated. At a low high-gravity level (β) = 47, nanoemulsion droplets were 16.15 ± 0.42 nm with a PDI of 0.122 ± 0.021. The nanoemulsion’s size and active pharmaceutical ingredient (API) content remained stable at long-term (4 months) freeze–thaw and dilution experiments. At a high β = 188, the as-prepared nanocrystal was lamellar with a short diameter of about 200 nm and a long diameter of about 750 nm. In vitro performances demonstrated the nanoemulsion displayed higher cytotoxicity on MDA-MB-231 tumor cells, Caco-2 cell permeability and drug release than that of the nanocrystal, indicating that nanoemulsion should be an ideal alternative for dasatinib oral administration. |
| first_indexed | 2024-03-10T00:42:26Z |
| format | Article |
| id | doaj.art-f1e468104d1c4af8aa8960493424ee60 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T00:42:26Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-f1e468104d1c4af8aa8960493424ee602023-11-23T15:05:30ZengMDPI AGPharmaceutics1999-49232022-01-0114119710.3390/pharmaceutics14010197Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug DeliveryChuanqi Wang0Manting Wang1Peng Chen2Jiexin Wang3Yuan Le4State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, ChinaState Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, ChinaIn this work, dasatinib (DAS) nanoemulsion and nanocrystal are produced by high-gravity technology that approaches to practical mass production. The drug nanoformulations were systematically characterized and evaluated. At a low high-gravity level (β) = 47, nanoemulsion droplets were 16.15 ± 0.42 nm with a PDI of 0.122 ± 0.021. The nanoemulsion’s size and active pharmaceutical ingredient (API) content remained stable at long-term (4 months) freeze–thaw and dilution experiments. At a high β = 188, the as-prepared nanocrystal was lamellar with a short diameter of about 200 nm and a long diameter of about 750 nm. In vitro performances demonstrated the nanoemulsion displayed higher cytotoxicity on MDA-MB-231 tumor cells, Caco-2 cell permeability and drug release than that of the nanocrystal, indicating that nanoemulsion should be an ideal alternative for dasatinib oral administration.https://www.mdpi.com/1999-4923/14/1/197dasatinibnanoemulsionnanocrystalhigh-gravity technologyin vitro performances |
| spellingShingle | Chuanqi Wang Manting Wang Peng Chen Jiexin Wang Yuan Le Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery Pharmaceutics dasatinib nanoemulsion nanocrystal high-gravity technology in vitro performances |
| title | Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery |
| title_full | Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery |
| title_fullStr | Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery |
| title_full_unstemmed | Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery |
| title_short | Dasatinib Nanoemulsion and Nanocrystal for Enhanced Oral Drug Delivery |
| title_sort | dasatinib nanoemulsion and nanocrystal for enhanced oral drug delivery |
| topic | dasatinib nanoemulsion nanocrystal high-gravity technology in vitro performances |
| url | https://www.mdpi.com/1999-4923/14/1/197 |
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