Estimation of cell-free fetal DNA fraction from maternal plasma based on linkage disequilibrium information
Abstract Cell-free fetal DNA fraction (FF) in maternal plasma is a key parameter affecting the performance of noninvasive prenatal testing (NIPT). Accurate quantitation of FF plays a pivotal role in these tests. However, there are few methods that could determine FF with high accuracy using shallow‐...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-10-01
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| Series: | npj Genomic Medicine |
| Online Access: | https://doi.org/10.1038/s41525-021-00247-z |