Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy
Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated tr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
2017-06-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/60/1/0005/ |
| _version_ | 1811254149776408576 |
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| author | Kristýna Čáňová Lucie Rozkydalová Emil Rudolf |
| author_facet | Kristýna Čáňová Lucie Rozkydalová Emil Rudolf |
| author_sort | Kristýna Čáňová |
| collection | DOAJ |
| description | Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity. |
| first_indexed | 2024-04-12T17:01:56Z |
| format | Article |
| id | doaj.art-f1e5692187254ff7a1077116e41acc82 |
| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-12T17:01:56Z |
| publishDate | 2017-06-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-f1e5692187254ff7a1077116e41acc822022-12-22T03:24:03ZengKarolinum PressActa Medica1211-42861805-96942017-06-0160151110.14712/18059694.2017.444981Anthelmintic Flubendazole and Its Potential Use in Anticancer TherapyKristýna ČáňováLucie RozkydalováEmil RudolfFlubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity.https://actamedica.lfhk.cuni.cz/60/1/0005/flubendazolebenzimidazole carbamateanti-cancer treatmentmelanomamicrotubulesmitotic catastrophe |
| spellingShingle | Kristýna Čáňová Lucie Rozkydalová Emil Rudolf Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy Acta Medica flubendazole benzimidazole carbamate anti-cancer treatment melanoma microtubules mitotic catastrophe |
| title | Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy |
| title_full | Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy |
| title_fullStr | Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy |
| title_full_unstemmed | Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy |
| title_short | Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy |
| title_sort | anthelmintic flubendazole and its potential use in anticancer therapy |
| topic | flubendazole benzimidazole carbamate anti-cancer treatment melanoma microtubules mitotic catastrophe |
| url | https://actamedica.lfhk.cuni.cz/60/1/0005/ |
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