Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans
The taste of food plays a crucial role in determining what and how much we eat. Thus, interventions that temporarily block sweet taste receptors offer a promising approach to addressing unhealthy behaviours associated with sugary foods. However, the relationship between reduced sweet taste response...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023069414 |
| _version_ | 1827780420564942848 |
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| author | Raquel Rayo-Morales Antonio Segura-Carretero Isabel Borras-Linares David Garcia-Burgos |
| author_facet | Raquel Rayo-Morales Antonio Segura-Carretero Isabel Borras-Linares David Garcia-Burgos |
| author_sort | Raquel Rayo-Morales |
| collection | DOAJ |
| description | The taste of food plays a crucial role in determining what and how much we eat. Thus, interventions that temporarily block sweet taste receptors offer a promising approach to addressing unhealthy behaviours associated with sugary foods. However, the relationship between reduced sweet taste response and food consumption remains unclear, with contradictory findings. Certain studies suggest that a diminished perception of sweetness leads to a sense of fullness and results in reduced food intake, while others suggest the opposite effect. To shed some light, our systematic review looked into the relationship between diminished sweet taste response and food consumption by examining the effects of bioactive compounds that experimentally inhibit sweetness in healthy individuals. This review was registered in the International Prospective Register of Systematic Reviews and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Scottish Intercollegiate Guidelines Network, and covered original papers included in Web of Science, PubMed, Scopus, Food Science Source and Food Science and technology abstracts. We identified 33 peer-reviewed English-language studies that fit the topic and met the inclusion criteria. The current literature predominantly focuses on the immediate impact of oral gymnemic acids, failing to provide preliminary evidence in support of the specific threshold hypothesis, above which food consumption decreases and below which the opposite effect occurs. Additionally, there was inconsistency in the findings regarding the short-term desire to eat following sweetness inhibition. Considering the downstream effects on energy intake and their clinical applications, further research is needed to clarify both the acute within-session effects (i.e., not wanting any more now) and the longer-term effects (i.e., deciding not to start eating) linked to oral sweet-taste-suppressing compounds. |
| first_indexed | 2024-03-11T15:05:18Z |
| format | Article |
| id | doaj.art-f1e619a7c03b488195b0965d32d4d738 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:05:18Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-f1e619a7c03b488195b0965d32d4d7382023-10-30T06:05:19ZengElsevierHeliyon2405-84402023-10-01910e19733Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humansRaquel Rayo-Morales0Antonio Segura-Carretero1Isabel Borras-Linares2David Garcia-Burgos3Department of Analytical Chemistry, Faculty of Science, University of Granada, 18071 Granada, Spain; Department of Psychobiology, Institute of Neurosciences, Centre for Biomedical Research, University of Granada, 18010, Granada, SpainDepartment of Analytical Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainDepartment of Analytical Chemistry, Faculty of Science, University of Granada, 18071 Granada, SpainDepartment of Psychobiology, Institute of Neurosciences, Centre for Biomedical Research, University of Granada, 18010, Granada, Spain; Corresponding author. Institute of Neurosciences, University of Granada, Avda. del Conocimiento s/n, 18100, Armilla, Granada, Spain.The taste of food plays a crucial role in determining what and how much we eat. Thus, interventions that temporarily block sweet taste receptors offer a promising approach to addressing unhealthy behaviours associated with sugary foods. However, the relationship between reduced sweet taste response and food consumption remains unclear, with contradictory findings. Certain studies suggest that a diminished perception of sweetness leads to a sense of fullness and results in reduced food intake, while others suggest the opposite effect. To shed some light, our systematic review looked into the relationship between diminished sweet taste response and food consumption by examining the effects of bioactive compounds that experimentally inhibit sweetness in healthy individuals. This review was registered in the International Prospective Register of Systematic Reviews and conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and the Scottish Intercollegiate Guidelines Network, and covered original papers included in Web of Science, PubMed, Scopus, Food Science Source and Food Science and technology abstracts. We identified 33 peer-reviewed English-language studies that fit the topic and met the inclusion criteria. The current literature predominantly focuses on the immediate impact of oral gymnemic acids, failing to provide preliminary evidence in support of the specific threshold hypothesis, above which food consumption decreases and below which the opposite effect occurs. Additionally, there was inconsistency in the findings regarding the short-term desire to eat following sweetness inhibition. Considering the downstream effects on energy intake and their clinical applications, further research is needed to clarify both the acute within-session effects (i.e., not wanting any more now) and the longer-term effects (i.e., deciding not to start eating) linked to oral sweet-taste-suppressing compounds.http://www.sciencedirect.com/science/article/pii/S2405844023069414Anti-sweetDiet-induced obesityGymnema sylvestrePlant-derived bioactive compoundSugar consumptionSweet taste receptor |
| spellingShingle | Raquel Rayo-Morales Antonio Segura-Carretero Isabel Borras-Linares David Garcia-Burgos Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans Heliyon Anti-sweet Diet-induced obesity Gymnema sylvestre Plant-derived bioactive compound Sugar consumption Sweet taste receptor |
| title | Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans |
| title_full | Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans |
| title_fullStr | Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans |
| title_full_unstemmed | Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans |
| title_short | Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans |
| title_sort | suppression of sweet taste related responses by plant derived bioactive compounds and eating part i a systematic review in humans |
| topic | Anti-sweet Diet-induced obesity Gymnema sylvestre Plant-derived bioactive compound Sugar consumption Sweet taste receptor |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023069414 |
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