Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties
The optimized extraction process of natural matrices such as propolis that results in extracts with significant compounds has been one of the main needs of the industry. The aim of this work was to analyze the content of the active components of Brazilian red propolis extracts previously treated wit...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Applied Sciences |
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| Online Access: | https://www.mdpi.com/2076-3417/12/22/11741 |
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| author | Gabriele de Abreu Barreto Jamile Costa Cerqueira João Henrique de Oliveira Reis Katharine Valéria Saraiva Hodel Letícia Amaral Gama Jeancarlo Pereira Anjos Cintia Silva Minafra-Rezende Luciana Nalone Andrade Ricardo Guimarães Amaral Cláudia do Ó. Pessoa Maria Cláudia dos Santos Luciano Josiane Dantas Viana Barbosa Marcelo Andrés Umsza-Guez Bruna Aparecida Souza Machado |
| author_facet | Gabriele de Abreu Barreto Jamile Costa Cerqueira João Henrique de Oliveira Reis Katharine Valéria Saraiva Hodel Letícia Amaral Gama Jeancarlo Pereira Anjos Cintia Silva Minafra-Rezende Luciana Nalone Andrade Ricardo Guimarães Amaral Cláudia do Ó. Pessoa Maria Cláudia dos Santos Luciano Josiane Dantas Viana Barbosa Marcelo Andrés Umsza-Guez Bruna Aparecida Souza Machado |
| author_sort | Gabriele de Abreu Barreto |
| collection | DOAJ |
| description | The optimized extraction process of natural matrices such as propolis that results in extracts with significant compounds has been one of the main needs of the industry. The aim of this work was to analyze the content of the active components of Brazilian red propolis extracts previously treated with ultrasound, as well as to evaluate in vitro their performance regarding antioxidant capacity and against bacteria and tumor cells. The results of the chromatographic analysis showed the influence of ultrasound treatment for higher yields of formononetin and kaempferol. However, just a higher content of these two components was not enough to interfere with higher concentrations of phenolic compounds and flavonoids among the extracts. The ten extracts obtained showed activity against two bacterial strains, and eight of them showed >70% cytotoxicity against five neoplastic cell lines. These results demonstrated the influence of ultrasound technology as a pretreatment in obtaining the ethanolic extracts of propolis, increasing the possibility of the applicability of Brazilian red propolis in different areas. |
| first_indexed | 2024-03-09T18:29:51Z |
| format | Article |
| id | doaj.art-f1e69e353e73488eb8d8261a0f82723e |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-09T18:29:51Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-f1e69e353e73488eb8d8261a0f82723e2023-11-24T07:40:12ZengMDPI AGApplied Sciences2076-34172022-11-0112221174110.3390/app122211741Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological PropertiesGabriele de Abreu Barreto0Jamile Costa Cerqueira1João Henrique de Oliveira Reis2Katharine Valéria Saraiva Hodel3Letícia Amaral Gama4Jeancarlo Pereira Anjos5Cintia Silva Minafra-Rezende6Luciana Nalone Andrade7Ricardo Guimarães Amaral8Cláudia do Ó. Pessoa9Maria Cláudia dos Santos Luciano10Josiane Dantas Viana Barbosa11Marcelo Andrés Umsza-Guez12Bruna Aparecida Souza Machado13SENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilFaculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilSchool of Veterinary and Animal Science, Federal University of Goiás, Goiânia 40170-115, BrazilInstitute of Research and Technology (ITP), Tiradentes University, Aracaju 49032-490, BrazilDepartment of Physiology, Federal University of Sergipe, São Cristóvão 49100-000, BrazilDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza 60430-275, BrazilDepartment of Physiology and Pharmacology, Drug Research and Development Center, Federal University of Ceará, Fortaleza 60430-275, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilDepartment of Biotechnology, Health Science Institute, Federal University of Bahia, Salvador 40170-115, BrazilSENAI Institute of Innovation (ISI) in Health Advanced Systems (CIMATEC ISI SAS), SENAI CIMATEC University Center, Salvador 41650-010, BrazilThe optimized extraction process of natural matrices such as propolis that results in extracts with significant compounds has been one of the main needs of the industry. The aim of this work was to analyze the content of the active components of Brazilian red propolis extracts previously treated with ultrasound, as well as to evaluate in vitro their performance regarding antioxidant capacity and against bacteria and tumor cells. The results of the chromatographic analysis showed the influence of ultrasound treatment for higher yields of formononetin and kaempferol. However, just a higher content of these two components was not enough to interfere with higher concentrations of phenolic compounds and flavonoids among the extracts. The ten extracts obtained showed activity against two bacterial strains, and eight of them showed >70% cytotoxicity against five neoplastic cell lines. These results demonstrated the influence of ultrasound technology as a pretreatment in obtaining the ethanolic extracts of propolis, increasing the possibility of the applicability of Brazilian red propolis in different areas.https://www.mdpi.com/2076-3417/12/22/11741red propolisformononetinkaempferolbioactive compoundscytotoxicity |
| spellingShingle | Gabriele de Abreu Barreto Jamile Costa Cerqueira João Henrique de Oliveira Reis Katharine Valéria Saraiva Hodel Letícia Amaral Gama Jeancarlo Pereira Anjos Cintia Silva Minafra-Rezende Luciana Nalone Andrade Ricardo Guimarães Amaral Cláudia do Ó. Pessoa Maria Cláudia dos Santos Luciano Josiane Dantas Viana Barbosa Marcelo Andrés Umsza-Guez Bruna Aparecida Souza Machado Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties Applied Sciences red propolis formononetin kaempferol bioactive compounds cytotoxicity |
| title | Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties |
| title_full | Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties |
| title_fullStr | Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties |
| title_full_unstemmed | Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties |
| title_short | Evaluation of the Potential of Brazilian Red Propolis Extracts: An Analysis of the Chemical Composition and Biological Properties |
| title_sort | evaluation of the potential of brazilian red propolis extracts an analysis of the chemical composition and biological properties |
| topic | red propolis formononetin kaempferol bioactive compounds cytotoxicity |
| url | https://www.mdpi.com/2076-3417/12/22/11741 |
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