Research progress on metabonomic studies in periodontitis
Metabolomics reflects the endogenous metabolite changes in organisms through qualitative and quantitative detection of small molecules in biological samples, revealing the metabolic changes during disease development. Metabolomic studies of periodontitis further elucidate the etiology, diagnosis and...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
2023-03-01
|
| Series: | 口腔疾病防治 |
| Subjects: | |
| Online Access: | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.03.009 |
| _version_ | 1828086566392692736 |
|---|---|
| author | ZHAO Rui HUANG Jin FANG Ming TIAN Min |
| author_facet | ZHAO Rui HUANG Jin FANG Ming TIAN Min |
| author_sort | ZHAO Rui |
| collection | DOAJ |
| description | Metabolomics reflects the endogenous metabolite changes in organisms through qualitative and quantitative detection of small molecules in biological samples, revealing the metabolic changes during disease development. Metabolomic studies of periodontitis further elucidate the etiology, diagnosis and predictive markers of periodontitis at the levels of metabolites and metabolic pathways. In this paper, the concept and research methods of metabonomics were summarized, and the current status of the metabonomics of saliva and gingival crevicular fluid in the study of periodontitis was reviewed. Previous studies have shown that metabolites such as short-chain fatty acids and amino acids and metabolic pathways such as glutamic acid and pyrimidine metabolism might promote the occurrence of periodontitis, and it was suggested that lactic acid, γ-amino-butyrate, butyric acid and lysophosphatidic acid might be potential diagnostic markers of periodontitis. The metabolomics study of periodontitis still faces challenges such as high heterogeneity of results and fluctuation of metabolites. In the future, its study could be optimized through multicenter prospective studies to provide fresh approaches for the etiology and diagnosis of periodontitis.
|
| first_indexed | 2024-04-11T04:58:13Z |
| format | Article |
| id | doaj.art-f1e6f0927b344a56b192ddb993d352f3 |
| institution | Directory Open Access Journal |
| issn | 2096-1456 |
| language | zho |
| last_indexed | 2024-04-11T04:58:13Z |
| publishDate | 2023-03-01 |
| publisher | Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases |
| record_format | Article |
| series | 口腔疾病防治 |
| spelling | doaj.art-f1e6f0927b344a56b192ddb993d352f32022-12-26T08:26:09ZzhoEditorial Department of Journal of Prevention and Treatment for Stomatological Diseases口腔疾病防治2096-14562023-03-0131320721110.12016/j.issn.2096⁃1456.2023.03.009Research progress on metabonomic studies in periodontitisZHAO Rui0HUANG Jin 1FANG Ming2TIAN Min3State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, Hospital of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, Hospital of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, Hospital of Stomatology, the Fourth Military Medical UniversityState Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Department of Prosthodontics, Hospital of Stomatology, the Fourth Military Medical UniversityMetabolomics reflects the endogenous metabolite changes in organisms through qualitative and quantitative detection of small molecules in biological samples, revealing the metabolic changes during disease development. Metabolomic studies of periodontitis further elucidate the etiology, diagnosis and predictive markers of periodontitis at the levels of metabolites and metabolic pathways. In this paper, the concept and research methods of metabonomics were summarized, and the current status of the metabonomics of saliva and gingival crevicular fluid in the study of periodontitis was reviewed. Previous studies have shown that metabolites such as short-chain fatty acids and amino acids and metabolic pathways such as glutamic acid and pyrimidine metabolism might promote the occurrence of periodontitis, and it was suggested that lactic acid, γ-amino-butyrate, butyric acid and lysophosphatidic acid might be potential diagnostic markers of periodontitis. The metabolomics study of periodontitis still faces challenges such as high heterogeneity of results and fluctuation of metabolites. In the future, its study could be optimized through multicenter prospective studies to provide fresh approaches for the etiology and diagnosis of periodontitis. http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.03.009metabolomics ，nuclear magnetic resonance ，mass spectrometry ，chromatography ，periodontitis ，salivary，gingival crevicular fluid，diagnostic marker ，inflammation ，reactive oxygen species， |
| spellingShingle | ZHAO Rui HUANG Jin FANG Ming TIAN Min Research progress on metabonomic studies in periodontitis 口腔疾病防治 metabolomics ， nuclear magnetic resonance ， mass spectrometry ， chromatography ， periodontitis ， salivary， gingival crevicular fluid， diagnostic marker ， inflammation ， reactive oxygen species， |
| title | Research progress on metabonomic studies in periodontitis |
| title_full | Research progress on metabonomic studies in periodontitis |
| title_fullStr | Research progress on metabonomic studies in periodontitis |
| title_full_unstemmed | Research progress on metabonomic studies in periodontitis |
| title_short | Research progress on metabonomic studies in periodontitis |
| title_sort | research progress on metabonomic studies in periodontitis |
| topic | metabolomics ， nuclear magnetic resonance ， mass spectrometry ， chromatography ， periodontitis ， salivary， gingival crevicular fluid， diagnostic marker ， inflammation ， reactive oxygen species， |
| url | http://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2023.03.009 |
| work_keys_str_mv | AT zhaorui researchprogressonmetabonomicstudiesinperiodontitis AT huangjin researchprogressonmetabonomicstudiesinperiodontitis AT fangming researchprogressonmetabonomicstudiesinperiodontitis AT tianmin researchprogressonmetabonomicstudiesinperiodontitis |