PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME
Aim. To perform comparative analysis of the pregnancy-associated plasma protein A and insulin-like growth factor 1 (PAPP-A and IGF-1) in blood plasma of patients with acute coronary syndrome (ACS). Prediction of 24-hour risk of fatal outcome in ACS.Material and methods. The concentrations of PAPP-A...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2017-12-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/377 |
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| author | G. Kh. Kayumova V. A. Razin R. Kh. Gimaev V. I. Ruzov О. L. Arjamkina V. V. Gnoevykh |
| author_facet | G. Kh. Kayumova V. A. Razin R. Kh. Gimaev V. I. Ruzov О. L. Arjamkina V. V. Gnoevykh |
| author_sort | G. Kh. Kayumova |
| collection | DOAJ |
| description | Aim. To perform comparative analysis of the pregnancy-associated plasma protein A and insulin-like growth factor 1 (PAPP-A and IGF-1) in blood plasma of patients with acute coronary syndrome (ACS). Prediction of 24-hour risk of fatal outcome in ACS.Material and methods. The concentrations of PAPP-A and IGF-I were assessed in 71 ACS patients, mean age 57 y. o. In the study group, during 24 hours myocardial infarction (MI) was diagnosed in 44, unstable angina in 27, and 9 fatal outcomes. Also, the concentrations of PAPP-A and IGF-I were measured in comparison and control groups. Comparison consisted of 40 hypertension patients with stable ischemic heart disease. Controls were 20 almost healthy persons.Results. In the study, there was increase of PAPP-A and IGF-I levels in ACS patients. In unstable angina patients PAPP-A is higher than in controls 3,56 times, and in MI patients 11,6 times. In MI, PAPP-A is 3,2 times higher than in unstable angina. In unstable angina patients there the highest levels of IGF-I, and 1,27 higher than in controls. In the study, we showed that IGF-I and PAPP-A levels in acute coronary pathology are linked to the outcome at the first day of the disease.Conclusion. It is aim full to apply PAPP-A and IGF-I to urgent cardiology practice as an analyzer of atherosclerotic plaque instability in acute coronary events, as a factor of life and disease prognosis. |
| first_indexed | 2024-04-10T03:35:42Z |
| format | Article |
| id | doaj.art-f1e8c6fcdf4f4867ad7885b4893b2808 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:35:42Z |
| publishDate | 2017-12-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-f1e8c6fcdf4f4867ad7885b4893b28082023-03-13T07:23:26Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252017-12-01166707510.15829/1728-8800-2017-6-70-75497PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROMEG. Kh. Kayumova0V. A. Razin1R. Kh. Gimaev2V. I. Ruzov3О. L. Arjamkina4V. V. Gnoevykh5ООО "ВМ Клиник"; ФГОУ ВО "Ульяновский государственный университет"ФГОУ ВО “Ульяновский государственный университет”ФГОУ ВО “Ульяновский государственный университет”ФГОУ ВО “Ульяновский государственный университет”ФГОУ ВО “Ульяновский государственный университет”ФГОУ ВО “Ульяновский государственный университет”Aim. To perform comparative analysis of the pregnancy-associated plasma protein A and insulin-like growth factor 1 (PAPP-A and IGF-1) in blood plasma of patients with acute coronary syndrome (ACS). Prediction of 24-hour risk of fatal outcome in ACS.Material and methods. The concentrations of PAPP-A and IGF-I were assessed in 71 ACS patients, mean age 57 y. o. In the study group, during 24 hours myocardial infarction (MI) was diagnosed in 44, unstable angina in 27, and 9 fatal outcomes. Also, the concentrations of PAPP-A and IGF-I were measured in comparison and control groups. Comparison consisted of 40 hypertension patients with stable ischemic heart disease. Controls were 20 almost healthy persons.Results. In the study, there was increase of PAPP-A and IGF-I levels in ACS patients. In unstable angina patients PAPP-A is higher than in controls 3,56 times, and in MI patients 11,6 times. In MI, PAPP-A is 3,2 times higher than in unstable angina. In unstable angina patients there the highest levels of IGF-I, and 1,27 higher than in controls. In the study, we showed that IGF-I and PAPP-A levels in acute coronary pathology are linked to the outcome at the first day of the disease.Conclusion. It is aim full to apply PAPP-A and IGF-I to urgent cardiology practice as an analyzer of atherosclerotic plaque instability in acute coronary events, as a factor of life and disease prognosis.https://cardiovascular.elpub.ru/jour/article/view/377острый коронарный синдроминфаркт миокардаассоциированный с беременностью протеин плазмы-аинсулиноподобный фактор роста 1ишемическая болезнь сердцанестабильная стенокардия |
| spellingShingle | G. Kh. Kayumova V. A. Razin R. Kh. Gimaev V. I. Ruzov О. L. Arjamkina V. V. Gnoevykh PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME Кардиоваскулярная терапия и профилактика острый коронарный синдром инфаркт миокарда ассоциированный с беременностью протеин плазмы-а инсулиноподобный фактор роста 1 ишемическая болезнь сердца нестабильная стенокардия |
| title | PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME |
| title_full | PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME |
| title_fullStr | PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME |
| title_full_unstemmed | PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME |
| title_short | PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME |
| title_sort | prognosis of one day mortality and protein growth and damage factors in acute coronary syndrome |
| topic | острый коронарный синдром инфаркт миокарда ассоциированный с беременностью протеин плазмы-а инсулиноподобный фактор роста 1 ишемическая болезнь сердца нестабильная стенокардия |
| url | https://cardiovascular.elpub.ru/jour/article/view/377 |
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