Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization

Brains and blood of Alzheimer’s disease (AD) patients have shown elevated mercury concentrations, but potential involvement of mercury exposure in AD pathogenesis has not been studied at the molecular level. The pathological hallmark of AD brains is deposition of amyloid plaques, consistin...

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Bibliographic Details
Main Authors: Cecilia Wallin, Merlin Friedemann, Sabrina B. Sholts, Andra Noormägi, Teodor Svantesson, Jüri Jarvet, Per M. Roos, Peep Palumaa, Astrid Gräslund, Sebastian K. T. S. Wärmländer
Format: Article
Language:English
Published: MDPI AG 2019-12-01
Series:Biomolecules
Subjects:
mercury
alzheimer’s disease
amyloid aggregation
metal–protein binding
neurodegeneration
Online Access:https://www.mdpi.com/2218-273X/10/1/44

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