Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report
Parkinson's disease (PD) manifestations can include visual hallucinations and illusions. Recent findings suggest that the coherent integration of bodily information within an egocentric representation could play a crucial role in these phenomena. Egocentric processing is a key aspect of spatial...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.992498/full |
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| author | Cosimo Tuena Giuseppe Riva Giuseppe Riva Immacolata Murru Luca Campana Karine M. Goulene Elisa Pedroli Marco Stramba-Badiale |
| author_facet | Cosimo Tuena Giuseppe Riva Giuseppe Riva Immacolata Murru Luca Campana Karine M. Goulene Elisa Pedroli Marco Stramba-Badiale |
| author_sort | Cosimo Tuena |
| collection | DOAJ |
| description | Parkinson's disease (PD) manifestations can include visual hallucinations and illusions. Recent findings suggest that the coherent integration of bodily information within an egocentric representation could play a crucial role in these phenomena. Egocentric processing is a key aspect of spatial navigation and is supported by the striatum. Due to the deterioration of the striatal and motor systems, PD mainly impairs the egocentric rather than the allocentric spatial frame of reference. However, it is still unclear the interplay between spatial cognition and PD hallucinations and how different navigation mechanisms can influence such spatial frames of reference. We report the case of A.A., a patient that suffers from PD with frequent episodes of visual hallucinations and illusions. We used a virtual reality (VR) navigation task to assess egocentric and allocentric spatial memory under five navigation conditions (passive, immersive, map, path decision, and attentive cues) in A.A. and a PD control group without psychosis. In general, A.A. exhibited a statistically significant classical dissociation between the egocentric and allocentric performance with a greater deficit for the former. In particular, the dissociation was statistically significant in the “passive” and “attentive cues” conditions. Interestingly in the “immersive” condition, the dissociation was not significant and, in contrast to the other conditions, trends showed better performance for egocentric than allocentric memory. Within the theories of embodiment, we suggest that body-based information, as assessed with VR navigation tasks, could play an important role in PD hallucinations. In addition, the possible neural underpinnings and the usefulness of VR are discussed. |
| first_indexed | 2024-04-11T16:43:11Z |
| format | Article |
| id | doaj.art-f1eb1e94c3c54e068adef760c1f9dec6 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-11T16:43:11Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-f1eb1e94c3c54e068adef760c1f9dec62022-12-22T04:13:37ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532022-10-011610.3389/fnbeh.2022.992498992498Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case reportCosimo Tuena0Giuseppe Riva1Giuseppe Riva2Immacolata Murru3Luca Campana4Karine M. Goulene5Elisa Pedroli6Marco Stramba-Badiale7Applied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Milan, ItalyApplied Technology for Neuro-Psychology Lab, IRCCS Istituto Auxologico Italiano, Milan, ItalyHumane Technology Lab, Università Cattolica del Sacro Cuore, Milan, ItalyDepartment of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, ItalyDepartment of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico Italiano, Milan, ItalyFaculty of Psychology, Università eCampus, Novedrate, ItalyDepartment of Geriatrics and Cardiovascular Medicine, IRCCS Istituto Auxologico Italiano, Milan, ItalyParkinson's disease (PD) manifestations can include visual hallucinations and illusions. Recent findings suggest that the coherent integration of bodily information within an egocentric representation could play a crucial role in these phenomena. Egocentric processing is a key aspect of spatial navigation and is supported by the striatum. Due to the deterioration of the striatal and motor systems, PD mainly impairs the egocentric rather than the allocentric spatial frame of reference. However, it is still unclear the interplay between spatial cognition and PD hallucinations and how different navigation mechanisms can influence such spatial frames of reference. We report the case of A.A., a patient that suffers from PD with frequent episodes of visual hallucinations and illusions. We used a virtual reality (VR) navigation task to assess egocentric and allocentric spatial memory under five navigation conditions (passive, immersive, map, path decision, and attentive cues) in A.A. and a PD control group without psychosis. In general, A.A. exhibited a statistically significant classical dissociation between the egocentric and allocentric performance with a greater deficit for the former. In particular, the dissociation was statistically significant in the “passive” and “attentive cues” conditions. Interestingly in the “immersive” condition, the dissociation was not significant and, in contrast to the other conditions, trends showed better performance for egocentric than allocentric memory. Within the theories of embodiment, we suggest that body-based information, as assessed with VR navigation tasks, could play an important role in PD hallucinations. In addition, the possible neural underpinnings and the usefulness of VR are discussed.https://www.frontiersin.org/articles/10.3389/fnbeh.2022.992498/fullembodimentvirtual realityspatial navigationLewy bodiespsychosis |
| spellingShingle | Cosimo Tuena Giuseppe Riva Giuseppe Riva Immacolata Murru Luca Campana Karine M. Goulene Elisa Pedroli Marco Stramba-Badiale Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report Frontiers in Behavioral Neuroscience embodiment virtual reality spatial navigation Lewy bodies psychosis |
| title | Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report |
| title_full | Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report |
| title_fullStr | Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report |
| title_full_unstemmed | Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report |
| title_short | Contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to Parkinson's disease: A case report |
| title_sort | contribution of cognitive and bodily navigation cues to egocentric and allocentric spatial memory in hallucinations due to parkinson s disease a case report |
| topic | embodiment virtual reality spatial navigation Lewy bodies psychosis |
| url | https://www.frontiersin.org/articles/10.3389/fnbeh.2022.992498/full |
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