Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant <i>Pseudomonas aeruginosa</i>: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

Combination Therapy with Ciprofloxacin and Pentamidine against Multidrug-Resistant <i>Pseudomonas aeruginosa</i>: Assessment of In Vitro and In Vivo Efficacy and the Role of Resistance–Nodulation–Division (RND) Efflux Pumps

The aim of this work was to (i) evaluate the efficacy of a combination treatment of pentamidine with ciprofloxacin against <i>Galleria mellonella</i> larvae infected with an MDR strain of <i>P. aeruginosa</i> and (ii) determine if pentamidine acts as an efflux-pump inhibitor....

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Bibliographic Details
Main Authors: Megan Fletcher, Alex McCormack, Benjamin J. Parcell, Peter J. Coote
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Antibiotics
Subjects:
<i>Galleria mellonella</i>
drug repurposing
antibiotic resistance
synergy
efflux pump inhibitor
MexAB-OprM
Online Access:https://www.mdpi.com/2079-6382/12/8/1236

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