Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis
Abstract Objective We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | BMC Research Notes |
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| Online Access: | http://link.springer.com/article/10.1186/s13104-019-4540-5 |
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| author | Matthew B. Pickich Mark W. Hargrove C. Niles Phillips James C. Healy Angelique N. Moore Michael D. Roberts Jeffrey S. Martin |
| author_facet | Matthew B. Pickich Mark W. Hargrove C. Niles Phillips James C. Healy Angelique N. Moore Michael D. Roberts Jeffrey S. Martin |
| author_sort | Matthew B. Pickich |
| collection | DOAJ |
| description | Abstract Objective We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occurred when curcumin was given during induction of disease (preventative arm; 8-week WD with or without curcumin [8WD + C vs. 8WD]) as well as when given after disease development (treatment arm; 12-week WD with or without curcumin during weeks 9–12 [12WD + C vs. 12WD]). Herein, we sought to extend our findings from that study by determining the effects of curcumin supplementation on cytokine/chemokine expression in serum collected from these same rats. Results 24 cytokines/chemokines were assayed. IL-2 (+ 80%) and IL-13 (+ 83%) were greater with curcumin supplementation in the prevention arm. IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (− 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all). RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). Select serum cytokines/chemokines were affected with curcumin supplementation in this female rat model of NASH. Moreover, curcumin’s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation. |
| first_indexed | 2024-12-13T02:50:47Z |
| format | Article |
| id | doaj.art-f1ebd88853624614ae181dfff312c576 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-13T02:50:47Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-f1ebd88853624614ae181dfff312c5762022-12-22T00:02:04ZengBMCBMC Research Notes1756-05002019-08-011211710.1186/s13104-019-4540-5Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitisMatthew B. Pickich0Mark W. Hargrove1C. Niles Phillips2James C. Healy3Angelique N. Moore4Michael D. Roberts5Jeffrey S. Martin6Department of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusDepartment of Cell Biology and Physiology, Edward Via College of Osteopathic Medicine-Auburn CampusAbstract Objective We recently reported that curcumin supplementation in a metabolically (i.e., Western diet [WD]) and chemically (i.e., CCl4) induced female rat model of non-alcoholic steatohepatitis (NASH) was associated with lower liver pathology scores and molecular markers of inflammation. This occurred when curcumin was given during induction of disease (preventative arm; 8-week WD with or without curcumin [8WD + C vs. 8WD]) as well as when given after disease development (treatment arm; 12-week WD with or without curcumin during weeks 9–12 [12WD + C vs. 12WD]). Herein, we sought to extend our findings from that study by determining the effects of curcumin supplementation on cytokine/chemokine expression in serum collected from these same rats. Results 24 cytokines/chemokines were assayed. IL-2 (+ 80%) and IL-13 (+ 83%) were greater with curcumin supplementation in the prevention arm. IL-2 (+ 192%), IL-13 (+ 87%), IL-17A (+ 81%) and fractalkine (+ 121%) were higher while RANTES was lower (− 22%) with curcumin supplementation in the treatment arm (p < 0.05 for all). RANTES concentrations also correlated significantly with hepatic pathology scores of inflammation (r = 0.417, p = 0.008). Select serum cytokines/chemokines were affected with curcumin supplementation in this female rat model of NASH. Moreover, curcumin’s effect(s) on RANTES and its association with liver disease pathogenesis and progression may warrant further investigation.http://link.springer.com/article/10.1186/s13104-019-4540-5CurcuminTurmericInflammationNASHNAFLDCytokines |
| spellingShingle | Matthew B. Pickich Mark W. Hargrove C. Niles Phillips James C. Healy Angelique N. Moore Michael D. Roberts Jeffrey S. Martin Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis BMC Research Notes Curcumin Turmeric Inflammation NASH NAFLD Cytokines |
| title | Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| title_full | Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| title_fullStr | Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| title_full_unstemmed | Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| title_short | Effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| title_sort | effect of curcumin supplementation on serum expression of select cytokines and chemokines in a female rat model of nonalcoholic steatohepatitis |
| topic | Curcumin Turmeric Inflammation NASH NAFLD Cytokines |
| url | http://link.springer.com/article/10.1186/s13104-019-4540-5 |
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