Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI
BACKGROUND: Inflammation in the vascular wall plays an important role in the pathogenesis of atherosclerosis. Current studies have shown that increase of systemic inflammatory marker like the acute phase component C-reactive protein (CRP) are associated with an unfavorable progression of disease and...
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| Format: | Article |
| Language: | English |
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Secretariat of The Indonesian Biomedical Journal
2011-08-01
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| Series: | Indonesian Biomedical Journal |
| Online Access: | http://inabj.org/index.php/ibj/article/view/143 |
| _version_ | 1818952297832513536 |
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| author | Winni Agustiani Mansyur Arif Ilhamjaya Patellongi |
| author_facet | Winni Agustiani Mansyur Arif Ilhamjaya Patellongi |
| author_sort | Winni Agustiani |
| collection | DOAJ |
| description | BACKGROUND: Inflammation in the vascular wall plays an important role in the pathogenesis of atherosclerosis. Current studies have shown that increase of systemic inflammatory marker like the acute phase component C-reactive protein (CRP) are associated with an unfavorable progression of disease and an increased risk for acute cardiovascular events. Recently, a close association of Metabolic Syndrome (MetS) with hemostatic abnormalities has been reported. Among hemostatic abnormalities, an increase in plasminogen activator inhibitor (PAI)-1, a strong inhibitor of fibrinolysis, is considered a core feature of MetS. High PAI-1 concentrations may be associated with thrombus formation, also causing cardiovascular events. Therefore, we investigated the association between markers for chronic inflammation (CRP) and the markers of fibrinolytic impairment (PAI-1, PAP, TAFI) in subjects with central obesity. METHODS: This was a cross-sectional study in 80 male Indonesian subjects, aged 30-60 years old with central obesity, conducted from January to March 2008 in Bandung. RESULTS: The study results showed that there was a difference of PAI-1 levels between MetS and Non-MetS group. There were significant correlations between hsCRP and PAI-1 (r=0.252, p=0.024), hsCRP and PAP (r=0.253, p=0.024), and also between PAI-1 and PAP (r=-0.239, p=0.033) respectively. But, no correlation found between hsCRP and TAFI. CONCLUSIONS: There was correlation between inflammation and fibrinolysis impairment on central obesity. Concentrations oh hsCRP, PAI-1 and TAFI were significantly higher in MetS. KEYWORDS: inflammation, fibrinolysis impairment, hsCRP, PAI-1, PAP, TAFI. |
| first_indexed | 2024-12-20T09:48:09Z |
| format | Article |
| id | doaj.art-f1ed9225f45640e3999876e4af652b1e |
| institution | Directory Open Access Journal |
| issn | 2085-3297 2355-9179 |
| language | English |
| last_indexed | 2024-12-20T09:48:09Z |
| publishDate | 2011-08-01 |
| publisher | Secretariat of The Indonesian Biomedical Journal |
| record_format | Article |
| series | Indonesian Biomedical Journal |
| spelling | doaj.art-f1ed9225f45640e3999876e4af652b1e2022-12-21T19:44:42ZengSecretariat of The Indonesian Biomedical JournalIndonesian Biomedical Journal2085-32972355-91792011-08-01321273210.18585/inabj.v3i2.143135Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFIWinni Agustiani0Mansyur Arif1Ilhamjaya Patellongi2Faculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarFaculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarFaculty of Medicine, Hasanuddin University Jl. Perintis Kemerdekaan Km.10, MakassarBACKGROUND: Inflammation in the vascular wall plays an important role in the pathogenesis of atherosclerosis. Current studies have shown that increase of systemic inflammatory marker like the acute phase component C-reactive protein (CRP) are associated with an unfavorable progression of disease and an increased risk for acute cardiovascular events. Recently, a close association of Metabolic Syndrome (MetS) with hemostatic abnormalities has been reported. Among hemostatic abnormalities, an increase in plasminogen activator inhibitor (PAI)-1, a strong inhibitor of fibrinolysis, is considered a core feature of MetS. High PAI-1 concentrations may be associated with thrombus formation, also causing cardiovascular events. Therefore, we investigated the association between markers for chronic inflammation (CRP) and the markers of fibrinolytic impairment (PAI-1, PAP, TAFI) in subjects with central obesity. METHODS: This was a cross-sectional study in 80 male Indonesian subjects, aged 30-60 years old with central obesity, conducted from January to March 2008 in Bandung. RESULTS: The study results showed that there was a difference of PAI-1 levels between MetS and Non-MetS group. There were significant correlations between hsCRP and PAI-1 (r=0.252, p=0.024), hsCRP and PAP (r=0.253, p=0.024), and also between PAI-1 and PAP (r=-0.239, p=0.033) respectively. But, no correlation found between hsCRP and TAFI. CONCLUSIONS: There was correlation between inflammation and fibrinolysis impairment on central obesity. Concentrations oh hsCRP, PAI-1 and TAFI were significantly higher in MetS. KEYWORDS: inflammation, fibrinolysis impairment, hsCRP, PAI-1, PAP, TAFI.http://inabj.org/index.php/ibj/article/view/143 |
| spellingShingle | Winni Agustiani Mansyur Arif Ilhamjaya Patellongi Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI Indonesian Biomedical Journal |
| title | Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI |
| title_full | Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI |
| title_fullStr | Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI |
| title_full_unstemmed | Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI |
| title_short | Correlation between Inflammation and Fibrinolysis Impairment on Central Obesity: A Study for hsCRP, PAI-1, PAP and TAFI |
| title_sort | correlation between inflammation and fibrinolysis impairment on central obesity a study for hscrp pai 1 pap and tafi |
| url | http://inabj.org/index.php/ibj/article/view/143 |
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