Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice
<i>Background and objectives:</i> Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aime...
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MDPI AG
2019-09-01
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Series: | Medicina |
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author | Yutaka Matsumoto Sihui Ma Takaki Tominaga Keiko Yokoyama Kanae Kitatani Kazumasa Horikawa Katsuhiko Suzuki |
author_facet | Yutaka Matsumoto Sihui Ma Takaki Tominaga Keiko Yokoyama Kanae Kitatani Kazumasa Horikawa Katsuhiko Suzuki |
author_sort | Yutaka Matsumoto |
collection | DOAJ |
description | <i>Background and objectives:</i> Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. <i>Materials and Methods:</i> Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. <i>Results:</i> Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (<i>p</i> < 0.05). <i>Atgl</i> was significantly upregulated in the liver (<i>p</i> < 0.05), and <i>Atgl</i> upregulation in the liver was positively correlated with serum NEFA levels (<i>r</i> = 0.592, <i>p</i> < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (<i>FABPpm</i>, <i>FATP-1</i>, <i>FATP-3</i>, and <i>FATP-4</i>) expression in the skin after topical application of jojoba oil (<i>p</i> = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. <i>Conclusions:</i> Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin. |
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spelling | doaj.art-f1ef7e16970b4d989caa6a85524a00cd2023-09-03T02:47:42ZengMDPI AGMedicina1010-660X2019-09-0155959410.3390/medicina55090594medicina55090594Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in MiceYutaka Matsumoto0Sihui Ma1Takaki Tominaga2Keiko Yokoyama3Kanae Kitatani4Kazumasa Horikawa5Katsuhiko Suzuki6Faculty of Nursing, Tokai University School of Medicine, Isehara, Kanagawa 259-1292, JapanGraduate School of Sports Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanGraduate School of Sports Sciences, Waseda University, Tokorozawa, Saitama 359-1192, JapanSupport Center for Medical Research and Education, Tokai University, Isehara, Kanagawa 259-1292, JapanSupport Center for Medical Research and Education, Tokai University, Isehara, Kanagawa 259-1292, JapanFaculty of Nursing, Tokai University School of Medicine, Isehara, Kanagawa 259-1292, JapanFaculty of Sport Sciences, Waseda University, Tokorozawa, Saitama 359-1192, Japan<i>Background and objectives:</i> Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. <i>Materials and Methods:</i> Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. <i>Results:</i> Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (<i>p</i> < 0.05). <i>Atgl</i> was significantly upregulated in the liver (<i>p</i> < 0.05), and <i>Atgl</i> upregulation in the liver was positively correlated with serum NEFA levels (<i>r</i> = 0.592, <i>p</i> < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (<i>FABPpm</i>, <i>FATP-1</i>, <i>FATP-3</i>, and <i>FATP-4</i>) expression in the skin after topical application of jojoba oil (<i>p</i> = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. <i>Conclusions:</i> Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.https://www.mdpi.com/1010-660X/55/9/594jojoba oilfatty acidnon-esterified fatty acids (NEFA)aromatherapylipid metabolismtransdermal absorption |
spellingShingle | Yutaka Matsumoto Sihui Ma Takaki Tominaga Keiko Yokoyama Kanae Kitatani Kazumasa Horikawa Katsuhiko Suzuki Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice Medicina jojoba oil fatty acid non-esterified fatty acids (NEFA) aromatherapy lipid metabolism transdermal absorption |
title | Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice |
title_full | Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice |
title_fullStr | Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice |
title_full_unstemmed | Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice |
title_short | Acute Effects of Transdermal Administration of Jojoba Oil on Lipid Metabolism in Mice |
title_sort | acute effects of transdermal administration of jojoba oil on lipid metabolism in mice |
topic | jojoba oil fatty acid non-esterified fatty acids (NEFA) aromatherapy lipid metabolism transdermal absorption |
url | https://www.mdpi.com/1010-660X/55/9/594 |
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