(2<i>R</i>,6′<i>R,E</i>)-3′-(1-Aminoethylidene)-7-chloro-4,6-dimethoxy-6′-methyl-3<i>H</i>-spiro[benzofuran-2,1′-cyclohexane]-2′,3,4′-trione
A novel synthesis approach for griseofulvin derivatives was developed. The presented method is based on a two-stage process that includes preliminary acetylation of <i>griseofulvic</i> acid followed by condensation with ammonium acetate. The advantages of this protocol include readily av...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
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| Series: | Molbank |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-8599/2023/1/M1590 |
| Summary: | A novel synthesis approach for griseofulvin derivatives was developed. The presented method is based on a two-stage process that includes preliminary acetylation of <i>griseofulvic</i> acid followed by condensation with ammonium acetate. The advantages of this protocol include readily available starting materials and a simple target product isolation procedure. The structure of the synthesized polycyclic compound was approved by <sup>1</sup>H, <sup>13</sup>C-NMR spectroscopy, high-resolution mass spectrometry with electrospray ionization (ESI-HRMS), and X-ray diffraction. |
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| ISSN: | 1422-8599 |