Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report
A female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherap...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Technical Innovations & Patient Support in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405632423000227 |
| _version_ | 1797405391311601664 |
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| author | Takashi Saito Motohiro Murakami Taisuke Sumiya Daisuke Kobayashi Haruka Shirataki Den Fujioka Keiichiro Baba Hiroya Itagaki Yuri Tenjimbayashi Toyomi Satoh Hideyuki Sakurai |
| author_facet | Takashi Saito Motohiro Murakami Taisuke Sumiya Daisuke Kobayashi Haruka Shirataki Den Fujioka Keiichiro Baba Hiroya Itagaki Yuri Tenjimbayashi Toyomi Satoh Hideyuki Sakurai |
| author_sort | Takashi Saito |
| collection | DOAJ |
| description | A female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherapy (ISBT). Given the large size of the tumor, enhancement of the geometrical dose distribution was anticipated using ISBT. However, delivery of a sufficient dose to the high-risk clinical target volume was predicted to be challenging. Thus, RHT was incorporated to potentially augment the overall treatment effect. This unique combination of CRT, RHT and ISBT may be promising for management of large LACC and warrants further investigation. |
| first_indexed | 2024-03-09T03:09:30Z |
| format | Article |
| id | doaj.art-f1f2aeb57a154f4eb5e8f795c72f176e |
| institution | Directory Open Access Journal |
| issn | 2405-6324 |
| language | English |
| last_indexed | 2024-03-09T03:09:30Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Technical Innovations & Patient Support in Radiation Oncology |
| spelling | doaj.art-f1f2aeb57a154f4eb5e8f795c72f176e2023-12-04T05:23:25ZengElsevierTechnical Innovations & Patient Support in Radiation Oncology2405-63242023-12-0128100222Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case reportTakashi Saito0Motohiro Murakami1Taisuke Sumiya2Daisuke Kobayashi3Haruka Shirataki4Den Fujioka5Keiichiro Baba6Hiroya Itagaki7Yuri Tenjimbayashi8Toyomi Satoh9Hideyuki Sakurai10Department of Radiation Oncology, University of Tsukuba, Tsukuba, Japan; Corresponding author at: Departments of Radiation Oncology, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575 Japan.Department of Radiation Oncology, University of Tsukuba, Tsukuba, JapanDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JapanDepartment of Radiology, University of Tsukuba Hospital, Tsukuba, JapanDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JapanDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JapanDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Obstetrics and Gynecology, University of Tsukuba, Tsukuba, JapanDepartment of Radiation Oncology, University of Tsukuba, Tsukuba, JapanA female patient in her 50 s was found to have a 10-cm tumor resulting from locally advanced cervical cancer (LACC). Three-year relapse-free survival was achieved following a multimodal treatment strategy integrating chemoradiotherapy (CRT), regional hyperthermia (RHT), and interstitial brachytherapy (ISBT). Given the large size of the tumor, enhancement of the geometrical dose distribution was anticipated using ISBT. However, delivery of a sufficient dose to the high-risk clinical target volume was predicted to be challenging. Thus, RHT was incorporated to potentially augment the overall treatment effect. This unique combination of CRT, RHT and ISBT may be promising for management of large LACC and warrants further investigation.http://www.sciencedirect.com/science/article/pii/S2405632423000227Cervical cancerChemoradiotherapyHyperthermiaBrachytherapyMultimodal treatment |
| spellingShingle | Takashi Saito Motohiro Murakami Taisuke Sumiya Daisuke Kobayashi Haruka Shirataki Den Fujioka Keiichiro Baba Hiroya Itagaki Yuri Tenjimbayashi Toyomi Satoh Hideyuki Sakurai Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report Technical Innovations & Patient Support in Radiation Oncology Cervical cancer Chemoradiotherapy Hyperthermia Brachytherapy Multimodal treatment |
| title | Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report |
| title_full | Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report |
| title_fullStr | Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report |
| title_full_unstemmed | Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report |
| title_short | Multimodal treatment with chemoradiotherapy, regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer: A case report |
| title_sort | multimodal treatment with chemoradiotherapy regional hyperthermia and interstitial brachytherapy for a huge locally advanced cervical cancer a case report |
| topic | Cervical cancer Chemoradiotherapy Hyperthermia Brachytherapy Multimodal treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2405632423000227 |
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