Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

Activation of the sigma-1 receptor exerts cardioprotection in a rodent model of chronic heart failure by stimulation of angiogenesis

Abstract Background Angiogenesis plays a critical role on post-infarction heart failure (PIHF), the presence of which facilitates additional blood supply to maintain the survival of residual cardiomyocytes. The sigma-1 receptor (S1R) has been substantiated to stimulate angiogenesis, with the effect...

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Bibliographic Details
Main Authors: Xin Zhao, Xin Liu, Xiuhuan Chen, Xueyu Han, Yazhou Sun, Yuhong Fo, Xiukun Wang, Chuan Qu, Bo Yang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Molecular Medicine
Subjects:
The sigma-1 receptor
Heart failure
Angiogenesis
JAK2/STAT3
Online Access:https://doi.org/10.1186/s10020-022-00517-1

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