Dual Modulator of ASIC Channels and GABA<sub>A</sub> Receptors from Thyme Alters Fear-Related Hippocampal Activity

Dual Modulator of ASIC Channels and GABA<sub>A</sub> Receptors from Thyme Alters Fear-Related Hippocampal Activity

Acid-sensing ion channels (ASICs) are proton-gated ion channels that mediate nociception in the peripheral nervous system and contribute to fear and learning in the central nervous system. Sevanol was reported previously as a naturally-occurring ASIC inhibitor from thyme with favorable analgesic and...

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Bibliographic Details
Main Authors: Aleksandr P. Kalinovskii, Anton P. Pushkarev, Anastasia D. Mikhailenko, Denis S. Kudryavtsev, Olga A. Belozerova, Vladimir I. Shmygarev, Oleg N. Yatskin, Yuliya V. Korolkova, Sergey A. Kozlov, Dmitry I. Osmakov, Alexander Popov, Yaroslav A. Andreev
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
acid-sensing ion channels
γ-aminobutyric acid receptors
open field test
passive avoidance test
θ rhythm
anxiety
Online Access:https://www.mdpi.com/1422-0067/24/17/13148

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