A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

A Secreted Bacterial Peptidylarginine Deiminase Can Neutralize Human Innate Immune Defenses

ABSTRACT The keystone oral pathogen Porphyromonas gingivalis is associated with severe periodontitis. Intriguingly, this bacterium is known to secrete large amounts of an enzyme that converts peptidylarginine into citrulline residues. The present study was aimed at identifying possible functions of...

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Bibliographic Details
Main Authors: Tim Stobernack, Marines du Teil Espina, Lianne M. Mulder, Laura M. Palma Medina, Dillon R. Piebenga, Giorgio Gabarrini, Xin Zhao, Koen M. J. Janssen, Jarnick Hulzebos, Elisabeth Brouwer, Thomas Sura, Dörte Becher, Arie Jan van Winkelhoff, Friedrich Götz, Andreas Otto, Johanna Westra, Jan Maarten van Dijl
Format: Article
Language:English
Published: American Society for Microbiology 2018-11-01
Series:mBio
Subjects:
Porphyromonas gingivalis
citrullination
immune evasion
neutrophils
protein modification
Online Access:https://journals.asm.org/doi/10.1128/mBio.01704-18

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