Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia
BACKGROUND: Cancer patients are particularly vulnerable during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to evaluate clinical characteristics and mortality among cancer patients with COVID-19. METHODS: This retrospective, observational cohort study included 53 patients with...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Thoracic Medicine |
| Subjects: | |
| Online Access: | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2022;volume=17;issue=4;spage=220;epage=228;aulast=Ghaleb |
| _version_ | 1811180067014836224 |
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| author | Nabil Ghaleb Adeeb Bulkhi Eid Al-Qurashi Abdelfattah Touman Ahmad Aldobyany Rajaa Z Alsaggaf Hanan Mabar Noureen H Murtaza Ammar Rajab |
| author_facet | Nabil Ghaleb Adeeb Bulkhi Eid Al-Qurashi Abdelfattah Touman Ahmad Aldobyany Rajaa Z Alsaggaf Hanan Mabar Noureen H Murtaza Ammar Rajab |
| author_sort | Nabil Ghaleb |
| collection | DOAJ |
| description | BACKGROUND: Cancer patients are particularly vulnerable during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to evaluate clinical characteristics and mortality among cancer patients with COVID-19.
METHODS: This retrospective, observational cohort study included 53 patients with a malignancy and reverse-transcription polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus-2 infection in a tertiary care center in Mecca, Saudi Arabia, from March 14, 2020, to October 29, 2020. Clinical, laboratory, and radiological data were collected from institutional electronic records and analyzed.
RESULTS: Overall, 53 patients (62% male) were enrolled. The mean age of the patients was 54.9 ± 19.0 years, with 76% aged <65 years. The most common symptoms were fever (66%), dry cough (40%), and dyspnea (36%). Most infections (89%) were community acquired. Hematological malignancies (36%) were the most common cancer type. The most common solid tumors were breast cancer (23%) and colon cancer (9%). Just over half (51%) had a stage 4 tumor, and 30% of the patients had received chemotherapy within 2 weeks before the onset of COVID-19 symptoms. Initial chest radiographs showed pneumonia in 43% of patients; 38%, 9%, and 6% required oxygen support, intensive care unit admission, and invasive mechanical ventilation, respectively. The most common complication was secondary bacterial infection (13.2%). The all-cause mortality rate was 17%. In the multivariable logistic regression, dyspnea, leukocytosis, use of systemic steroids, and secondary bacterial infection were found to be risk factors for death.
CONCLUSION: Hospitalized cancer patients with COVID-19 have a high mortality rate. Our study finds a correlation between multiple independent risk factors and mortality. Patients with dyspnea, leukocytosis, systemic steroid use, or secondary bacterial infection require more care, attention, and possibly more aggressive treatment. |
| first_indexed | 2024-04-11T06:45:17Z |
| format | Article |
| id | doaj.art-f1f5d469591b462ebbed95f4744bb4c4 |
| institution | Directory Open Access Journal |
| issn | 1817-1737 1998-3557 |
| language | English |
| last_indexed | 2024-04-11T06:45:17Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Thoracic Medicine |
| spelling | doaj.art-f1f5d469591b462ebbed95f4744bb4c42022-12-22T04:39:23ZengWolters Kluwer Medknow PublicationsAnnals of Thoracic Medicine1817-17371998-35572022-01-0117422022810.4103/atm.atm_91_22Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi ArabiaNabil GhalebAdeeb BulkhiEid Al-QurashiAbdelfattah ToumanAhmad AldobyanyRajaa Z AlsaggafHanan MabarNoureen H MurtazaAmmar RajabBACKGROUND: Cancer patients are particularly vulnerable during the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to evaluate clinical characteristics and mortality among cancer patients with COVID-19. METHODS: This retrospective, observational cohort study included 53 patients with a malignancy and reverse-transcription polymerase chain reaction-confirmed severe acute respiratory syndrome coronavirus-2 infection in a tertiary care center in Mecca, Saudi Arabia, from March 14, 2020, to October 29, 2020. Clinical, laboratory, and radiological data were collected from institutional electronic records and analyzed. RESULTS: Overall, 53 patients (62% male) were enrolled. The mean age of the patients was 54.9 ± 19.0 years, with 76% aged <65 years. The most common symptoms were fever (66%), dry cough (40%), and dyspnea (36%). Most infections (89%) were community acquired. Hematological malignancies (36%) were the most common cancer type. The most common solid tumors were breast cancer (23%) and colon cancer (9%). Just over half (51%) had a stage 4 tumor, and 30% of the patients had received chemotherapy within 2 weeks before the onset of COVID-19 symptoms. Initial chest radiographs showed pneumonia in 43% of patients; 38%, 9%, and 6% required oxygen support, intensive care unit admission, and invasive mechanical ventilation, respectively. The most common complication was secondary bacterial infection (13.2%). The all-cause mortality rate was 17%. In the multivariable logistic regression, dyspnea, leukocytosis, use of systemic steroids, and secondary bacterial infection were found to be risk factors for death. CONCLUSION: Hospitalized cancer patients with COVID-19 have a high mortality rate. Our study finds a correlation between multiple independent risk factors and mortality. Patients with dyspnea, leukocytosis, systemic steroid use, or secondary bacterial infection require more care, attention, and possibly more aggressive treatment.http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2022;volume=17;issue=4;spage=220;epage=228;aulast=Ghalebcancercovid-19mortalitysaudi arabia |
| spellingShingle | Nabil Ghaleb Adeeb Bulkhi Eid Al-Qurashi Abdelfattah Touman Ahmad Aldobyany Rajaa Z Alsaggaf Hanan Mabar Noureen H Murtaza Ammar Rajab Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia Annals of Thoracic Medicine cancer covid-19 mortality saudi arabia |
| title | Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia |
| title_full | Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia |
| title_fullStr | Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia |
| title_full_unstemmed | Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia |
| title_short | Clinical characteristics and risk factors for mortality of hospitalized cancer patients with COVID-2019 in Mecca, Saudi Arabia |
| title_sort | clinical characteristics and risk factors for mortality of hospitalized cancer patients with covid 2019 in mecca saudi arabia |
| topic | cancer covid-19 mortality saudi arabia |
| url | http://www.thoracicmedicine.org/article.asp?issn=1817-1737;year=2022;volume=17;issue=4;spage=220;epage=228;aulast=Ghaleb |
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