Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid.
<h4>Purpose</h4>To create vortex vein congestion in the monkey eye as a possible pachychoroid model.<h4>Methods</h4>We ligated superotemporal and inferotemporal vortex veins at the surface of the sclera in monkey eyes. Optical coherence tomography (OCT) and indocyanine green...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0274137 |
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| author | Hidetaka Matsumoto Ryo Mukai Kazuma Saito Junki Hoshino Shoji Kishi Hideo Akiyama |
| author_facet | Hidetaka Matsumoto Ryo Mukai Kazuma Saito Junki Hoshino Shoji Kishi Hideo Akiyama |
| author_sort | Hidetaka Matsumoto |
| collection | DOAJ |
| description | <h4>Purpose</h4>To create vortex vein congestion in the monkey eye as a possible pachychoroid model.<h4>Methods</h4>We ligated superotemporal and inferotemporal vortex veins at the surface of the sclera in monkey eyes. Optical coherence tomography (OCT) and indocyanine green angiography (ICGA) were performed before and 2, 7, and 28 days after the vortex vein ligations to investigate changes in vortex vein morphology and alterations in choroidal blood flow.<h4>Results</h4>Before the vortex vein ligations, en face OCT and ICGA images showed well organized vortex veins as well as horizontal and vertical watershed zones. Two days after the vortex vein ligations, dilatation of the superotemporal and inferotemporal vortex veins as well as intervortex venous anastomoses were seen on en face OCT and ICGA images. B-mode OCT images showed choroidal thickening associated with dilatation of the outer choroidal vessels. Moreover, video ICGA revealed choriocapillaris filling delay and pulsatile flow in the dilated vortex veins. At 7 and 28 days after we ligated the vortex veins, these findings were reduced, except for the intervortex venous anastomoses.<h4>Conclusions</h4>We created a monkey model of vortex vein congestion by ligating two vortex veins. This animal model demonstrated pachychoroid-related findings, indicating that vortex vein congestion is involved in the pathogenesis of pachychoroid. However, remodeling of the choroidal drainage route via intervortex venous anastomosis appeared to compensate for the vortex vein congestion created in this model. |
| first_indexed | 2024-04-12T03:04:32Z |
| format | Article |
| id | doaj.art-f1f621132d50494b82b7d74a054200ad |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T03:04:32Z |
| publishDate | 2022-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f1f621132d50494b82b7d74a054200ad2022-12-22T03:50:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032022-01-01179e027413710.1371/journal.pone.0274137Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid.Hidetaka MatsumotoRyo MukaiKazuma SaitoJunki HoshinoShoji KishiHideo Akiyama<h4>Purpose</h4>To create vortex vein congestion in the monkey eye as a possible pachychoroid model.<h4>Methods</h4>We ligated superotemporal and inferotemporal vortex veins at the surface of the sclera in monkey eyes. Optical coherence tomography (OCT) and indocyanine green angiography (ICGA) were performed before and 2, 7, and 28 days after the vortex vein ligations to investigate changes in vortex vein morphology and alterations in choroidal blood flow.<h4>Results</h4>Before the vortex vein ligations, en face OCT and ICGA images showed well organized vortex veins as well as horizontal and vertical watershed zones. Two days after the vortex vein ligations, dilatation of the superotemporal and inferotemporal vortex veins as well as intervortex venous anastomoses were seen on en face OCT and ICGA images. B-mode OCT images showed choroidal thickening associated with dilatation of the outer choroidal vessels. Moreover, video ICGA revealed choriocapillaris filling delay and pulsatile flow in the dilated vortex veins. At 7 and 28 days after we ligated the vortex veins, these findings were reduced, except for the intervortex venous anastomoses.<h4>Conclusions</h4>We created a monkey model of vortex vein congestion by ligating two vortex veins. This animal model demonstrated pachychoroid-related findings, indicating that vortex vein congestion is involved in the pathogenesis of pachychoroid. However, remodeling of the choroidal drainage route via intervortex venous anastomosis appeared to compensate for the vortex vein congestion created in this model.https://doi.org/10.1371/journal.pone.0274137 |
| spellingShingle | Hidetaka Matsumoto Ryo Mukai Kazuma Saito Junki Hoshino Shoji Kishi Hideo Akiyama Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. PLoS ONE |
| title | Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. |
| title_full | Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. |
| title_fullStr | Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. |
| title_full_unstemmed | Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. |
| title_short | Vortex vein congestion in the monkey eye: A possible animal model of pachychoroid. |
| title_sort | vortex vein congestion in the monkey eye a possible animal model of pachychoroid |
| url | https://doi.org/10.1371/journal.pone.0274137 |
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