Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents
OBJECTIVES: To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents. METHODS: This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68). RESULTS: As expected, ob...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2018-10-01
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100262&lng=en&tlng=en |
| _version_ | 1818555876539105280 |
|---|---|
| author | Maria Camila Pruper de Freitas Diana Gabriela Estevez Fernandez Danielle Cohen Antônio Martins Figueiredo-Neto Raul Cavalcante Maranhão Nágila Raquel Teixeira Damasceno |
| author_facet | Maria Camila Pruper de Freitas Diana Gabriela Estevez Fernandez Danielle Cohen Antônio Martins Figueiredo-Neto Raul Cavalcante Maranhão Nágila Raquel Teixeira Damasceno |
| author_sort | Maria Camila Pruper de Freitas |
| collection | DOAJ |
| description | OBJECTIVES: To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents. METHODS: This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68). RESULTS: As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents. CONCLUSIONS: Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents. |
| first_indexed | 2024-12-12T14:59:04Z |
| format | Article |
| id | doaj.art-f1f759547a5b430497b515cfa814c8bd |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-12T14:59:04Z |
| publishDate | 2018-10-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-f1f759547a5b430497b515cfa814c8bd2022-12-22T00:20:50ZengElsevier EspañaClinics1980-53222018-10-0173010.6061/clinics/2018/e189S1807-59322018000100262Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescentsMaria Camila Pruper de FreitasDiana Gabriela Estevez FernandezDanielle CohenAntônio Martins Figueiredo-NetoRaul Cavalcante MaranhãoNágila Raquel Teixeira DamascenoOBJECTIVES: To evaluate biomarkers associated with early cardiometabolic risk in obese adolescents. METHODS: This cross-sectional study included 137 adolescents of both sexes aged 10 to 19 years divided into a normal weight group (NW) (n=69) and an obese group (OB) (n=68). RESULTS: As expected, obesity showed positive associations with homeostatic model assessment for insulin resistance (HOMA-IR), triacylglycerol, insulin, plasma levels of non-esterified fatty acids, and cholesterol ester transfer protein activity and negative associations with plasma antioxidant levels. Plasma oxidized low-density lipoprotein (oxLDL) and electronegative low-density lipoprotein [LDL(-)] levels were significantly higher in the OB group. Higher tertiles of oxLDL were associated with increased values of body mass index; waist circumference; fatty mass percentage (%FM); and the atherogenic lipids non-high-density-lipoprotein cholesterol (non-HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B and triacylglycerol. Higher tertiles of LDL(-) were robustly associated with body mass index and waist circumference. Logistic regression models (odds ratios) confirmed that increased values of lipids and apolipoprotein B were associated with increased risk of oxLDL. For LDL(-), these associations were not significant, suggesting that another mechanism is involved in generating this particle in obese adolescents. CONCLUSIONS: Obese adolescents showed increased plasma LDL(-) and oxLDL, and obese girls had more LDL(-) than obese boys. Therefore, oxLDL is strongly and independently associated with classical cardiovascular risk factors, while increased levels of LDL(-) were influenced by body mass index, waist circumference and demographic parameters in obese adolescents.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100262&lng=en&tlng=enObesityAdolescentLipoproteinsLow-density Lipoprotein |
| spellingShingle | Maria Camila Pruper de Freitas Diana Gabriela Estevez Fernandez Danielle Cohen Antônio Martins Figueiredo-Neto Raul Cavalcante Maranhão Nágila Raquel Teixeira Damasceno Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents Clinics Obesity Adolescent Lipoproteins Low-density Lipoprotein |
| title | Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| title_full | Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| title_fullStr | Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| title_full_unstemmed | Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| title_short | Oxidized and electronegative low-density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| title_sort | oxidized and electronegative low density lipoprotein as potential biomarkers of cardiovascular risk in obese adolescents |
| topic | Obesity Adolescent Lipoproteins Low-density Lipoprotein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000100262&lng=en&tlng=en |
| work_keys_str_mv | AT mariacamilapruperdefreitas oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents AT dianagabrielaestevezfernandez oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents AT daniellecohen oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents AT antoniomartinsfigueiredoneto oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents AT raulcavalcantemaranhao oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents AT nagilaraquelteixeiradamasceno oxidizedandelectronegativelowdensitylipoproteinaspotentialbiomarkersofcardiovascularriskinobeseadolescents |