Novel genome-editing tools to model and correct primary immunodeficiencies

Novel genome-editing tools to model and correct primary immunodeficiencies

Severe combined immunodeficiency (SCID) and other severe non-SCID primary immunodeficiencies (non-SCID PID) can be treated by allogeneic hematopoietic stem cell transplantation, but when HLA-matched donors are lacking, this can be a high-risk procedure. Correcting the patient’s own hematopoietic ste...

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Bibliographic Details
Main Authors: Lisa M Ott De Bruin, Stefano eVolpi, Kiran eMusunuru
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Immunology
Subjects:
Nuclease
SCID
endonuclease
Cas9
PID
CRISPR/Cas9
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00250/full

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